Cat. No. 4529
Alternative Name: HPI-4
Chemical Name: 2,4-Dichloro-α-(3,4-4-oxo-2(1H)-quin
Biological ActivityHedgehog (Hh) pathway antagonist; blocks Sonic hedgehog (Shh)-induced Hh pathway activation (IC50 = 7 μM) downstream of Smo. Perturbs primary cilia formation; inhibits cytoplasmic AAA+ ATPase dynein-dependent microtubule gliding and ATPase activity.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Firestone et al (2012) Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein. Nature 484 7392. PMID: 22425997.
Hyman et al (2009) Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade. Proc.Natl.Acad.Sci.U.S.A. 106 14132. PMID: 19666565.
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Citations are publications that use Tocris products. Selected citations for Ciliobrevin A include:
Shin et al (2015) Autophagy Regulates Formation of Primary Cilia in Mefloquine-Treated Cells. Biomol Ther (Seoul) 23 327. PMID: 26157548.
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Keywords: Ciliobrevin A, supplier, CiliobrevinA, supplier, hedgehog, Hh, pathway, antagonists, blocks, inhibits, inhibitors, Smo, smoothened, patched, ciliogenesis, cilia, microtubules, dynein, cytoplasmic, AAA+, ATPase, HPI-4, Tocris Bioscience, Hedgehog Signaling Inhibitor products
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