Ciliobrevin A

Cat. No. 4529

Ciliobrevin A C17H9Cl2N3O2 [302803-72-1]

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Alternative Name: HPI-4

Chemical Name: 2,4-Dichloro-α-(3,4-4-oxo-2(1H)-quinazolinylidene)-β-oxobenzenepropanenitrile

Biological Activity

Hedgehog (Hh) pathway antagonist; blocks Sonic hedgehog (Shh)-induced Hh pathway activation (IC50 = 7 μM) downstream of Smo. Perturbs primary cilia formation; inhibits cytoplasmic AAA+ ATPase dynein-dependent microtubule gliding and ATPase activity.

Technical Data

Soluble to 100 mM in DMSO
>98 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Firestone et al (2012) Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein. Nature 484 7392. PMID: 22425997.

Hyman et al (2009) Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade. Proc.Natl.Acad.Sci.U.S.A. 106 14132. PMID: 19666565.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Ciliobrevin A include:

Shin et al (2015) Autophagy Regulates Formation of Primary Cilia in Mefloquine-Treated Cells. Biomol Ther (Seoul) 23 327. PMID: 26157548.

Do you know of a great paper that uses Ciliobrevin A from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: Ciliobrevin A, supplier, CiliobrevinA, supplier, hedgehog, Hh, pathway, antagonists, blocks, inhibits, inhibitors, Smo, smoothened, patched, ciliogenesis, cilia, microtubules, dynein, cytoplasmic, AAA+, ATPase, HPI-4, Tocris Bioscience, Hedgehog Signaling Inhibitor products

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