TC-I 15

Cat. No. 4527

TC-I 15 C23H28N4O6S2 [916734-43-5]

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Chemical Name: N-[[(4R)-5,5-Dimethyl-3-(phenylsulfonyl)-4-thiazolidinyl]carbonyl]-3-[[[(phenylmethyl)amino]carbonyl]amino]-L-alanine

Biological Activity

Potent α2β1 integrin inhibitor (IC50 values for the inhibition of human platelet adhesion to type I collagen are 12 and 715 nM for platelets under static conditions and under flow, respectively). Displays selectivity for α2β1 over αvβ3, α5β1, α6β1 and αIIbβ3 at concentrations exceeding 1000 nM. Reduces collagen IV production in mesangial cells. Active in vivo; prevents ferric chloride-induced clot formation in mice.

Licensing Information

Sold under license from the University of Pennsylvania.

Technical Data

M.Wt:
520.62
Formula:
C23H28N4O6S2
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in 1.1eq. NaOH
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
916734-43-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Borza et al (2012) Inhibition of integrin α2β1 ameliorates glomerular injury. J.Am.Soc.Nephrol. 23 1027. PMID: 22440900.

Miller et al (2009) Small-molecule inhibitors of integrin α2β1 that prevent pathological thrombus formation via an allosteric mechanism. Proc.Natl.Acad.Sci.U.S.A. 106 719. PMID: 19141632.

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Keywords: TC-I 15, supplier, TC-I15, integrins, receptors, a2b1, alpha2beta1, α2β1, inhibitors, inhibits, potent, selective, active, in, vivo, antithrombotics, collagen, Tocris Bioscience, Integrin Receptor Inhibitor products

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