Cat. No. 4527
Chemical Name: N-[[(4R)-5,5-Dimethyl-3-(phenylsulf
Biological ActivityPotent α2β1 integrin inhibitor (IC50 values for the inhibition of human platelet adhesion to type I collagen are 12 and 715 nM for platelets under static conditions and under flow, respectively). Displays selectivity for α2β1 over αvβ3, α5β1, α6β1 and αIIbβ3 at concentrations exceeding 1000 nM. Reduces collagen IV production in mesangial cells. Active in vivo; prevents ferric chloride-induced clot formation in mice.
Licensing InformationSold under license from the University of Pennsylvania.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Borza et al (2012) Inhibition of integrin α2β1 ameliorates glomerular injury. J.Am.Soc.Nephrol. 23 1027. PMID: 22440900.
Miller et al (2009) Small-molecule inhibitors of integrin α2β1 that prevent pathological thrombus formation via an allosteric mechanism. Proc.Natl.Acad.Sci.U.S.A. 106 719. PMID: 19141632.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses TC-I 15 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: TC-I 15, supplier, TC-I15, integrins, receptors, a2b1, alpha2beta1, α2β1, inhibitors, inhibits, potent, selective, active, in, vivo, antithrombotics, collagen, Tocris Bioscience, Integrin Receptor Inhibitor products
Find multiple products by catalog number
New Products in this Area
α5β1 integrin receptor antagonistFSL 1
TLR2/6 agonist (also a putative TLR10 ligand)Cilengitide
Potent and selective inhibitor of integrins αvβ3 and αvβ5SM 324405
Potent TLR7 agonistRS 09
TLR4 peptide agonist; acts as an adjuvant in vivo
Follow Tocris on LinkedIn
Visit our LinkedIn page for the latest Tocris news, events and updates.