Cat. No. 4525
Alternative Name: RP 73401
Chemical Name: 3-(Cyclopentyloxy)-N-(3,5-dichloro-
Biological ActivityPotent and selective inhibitor of phosphodiesterase (PDE) 4 (IC50 = 1 nM at PDE4 from human neutrophils). Displays >19,000-fold selectivity over other PDE isoenzymes. Exhibits anti-inflammatory effects in models of allergic inflammation. Also inhibits LTB4 synthesis in human neutrophils (IC50 = 2 nM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Zhao et al (2003) Inhibitor binding to type 4 phosphodiesterase (PDE4) assessed using [3H]piclamilast and [3H]rolipram. J.Pharmacol.Exp.Ther. 305 565. PMID: 12704225.
Hatzelmann and Schudt (2001) Anti-inflammatory and immunomodulatory potential of the novel PDE4 inhibitor roflumilast in vitro. J.Pharmacol.Exp.Ther. 297 267. PMID: 11259554.
Raeburn et al (1994) Anti-inflammatory and bronchodilator properties of RP 73401, a novel and selective phosphodiesterase type IV inhibitor. Br.J.Pharmacol. 113 1423. PMID: 7889300.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses Piclamilast from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: Piclamilast, supplier, RP73401, phosphodiesterases, pde4, potent, selective, inhibitors, inhibits, Tocris Bioscience, Phosphodiesterase Inhibitor products
Find multiple products by catalog number
New Products in this Area
Fluorometric CYP450 substrateGaleterone
CYP17 inhibitor; also androgen receptor antagonistPF 04449613
Potent PDE9 inhibitor; brain penetrantEggmanone
Potent and selective PDE4 inhibitor; suppresses hedgehog signaling
Follow Tocris on LinkedIn
Visit our LinkedIn page for the latest Tocris news, events and updates.