Cat. No. 4524

EGCG C22H18O11 [989-51-5]

Price and Availability

For EGCG pricing & availability please select your country from the drop down menu:
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Name: Epigallocatechin gallate

Chemical Name: 3,4,5-Trihydroxybenzoic acid (2R,3R)-3,4-dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3-yl ester

Biological Activity

Inhibitor of amyloid assembly; inhibits the formation of amyloid fibrils by proteins such as Aβ, α-synuclein and huntingtin. Reduces Aβ42-induced cell death in three different cell types. Also inhibits β-secretase (IC50 = 1.6 μM) and glutamate dehydrogenase GDH. Inhibits cell growth and selectively induces apoptosis in A431 and human pancreatic cancer cells. Also a DNMT1 inhibitor.

Technical Data

Soluble to 10 mM in water and to 100 mM in ethanol
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Sinha et al (2012) Comparison of three amyloid assembly inhibitors: the sugar scyllo-inositol, the polyphenol epigallocatechin gallate, and the molecular tweezer CLR01. ACS Chem.Neurosci. 3 451. PMID: 22860214.

Yang et al (2009) Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signaling. Cancer Res. 69 7986. PMID: 19826036.

Shankar et al (2008) EGCG inhibits growth, invasion, angiogenesis and metastastasis of pancreatic cancer. Front.Biosci. 13 440. PMID: 17981559.

Lee et al (2005) Mechanisms for the inhibition of DNA methyltransferases by tea catechins and bioflavonoids. Mol.Pharmacol. 68 1018. PMID: 16037419.

Jeon et al (2003) Green tea catechins as a BACE1 (β-secretase) inhibitor. Bioorg.Med.Chem.Lett. 13 3905. PMID: 14592472.

Ahmad et al (2000) Green tea polyphenol epigallocatechin-3-gallate differentially modulates nuclear factor κB in cancer cells versus normal cells. Ach.Biochem.Biophys. 376 338. PMID: 10775421.

If you know of a relevant reference for EGCG please let us know.

Citations are publications that use Tocris products. Selected citations for EGCG include:

Eom et al (2015) Synergistic effect of curcumin on epigallocatechin gallate-induced anticancer action in PC3 prostate cancer cells. Allergy Asthma Immunol Res 48 461. PMID: 25441423.

Do you know of a great paper that uses EGCG from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: EGCG, supplier, BACE1, inhibitors, inhibits, β-secretase, b-secretase, beta-secretase, flavonoids, green, tea, antioxidants, neuroprotective, EGCG, epigallocatechin, gallate, amyloid, assembly, amyloidbeta, amyloidb, amyloidβ, glutamate, dehydrogenase, GDH, DNMT, DNA, Methyltransferases, Tocris Bioscience, Amyloid β Peptide Inhibitor products

Quick Order

Find multiple products by catalog number

divider line

Neurodegeneration Research Product Guide

Neurodegeneration Product Guide

Our Neurodegeneration guide highlights over 275 products for neurodegeneration research. Request copy or view PDF today.

divider line

Alzheimer's Life Science Poster

Written by Alan Palmer

Alzheimer's Life Science Poster

Our Alzheimer's disease poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease. Request copy or view PDF today.

divider line

New Products in this Area

RI 1

RAD51 recombinase inhibitor


PCNA inhibitor

Sign-up for new product e-alerts
divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.