Cat. No. 4524
Alternative Name: Epigallocatechin gallate
Chemical Name: 3,4,5-Trihydroxybenzoic acid (2R,3R)-3,4-dihydro-5,7-dihydroxy-2
Biological ActivityInhibitor of amyloid assembly; inhibits the formation of amyloid fibrils by proteins such as Aβ, α-synuclein and huntingtin. Reduces Aβ42-induced cell death in three different cell types. Also inhibits β-secretase (IC50 = 1.6 μM) and glutamate dehydrogenase GDH. Inhibits cell growth and selectively induces apoptosis in A431 and human pancreatic cancer cells. Also a DNMT1 inhibitor.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Sinha et al (2012) Comparison of three amyloid assembly inhibitors: the sugar scyllo-inositol, the polyphenol epigallocatechin gallate, and the molecular tweezer CLR01. ACS Chem.Neurosci. 3 451. PMID: 22860214.
Yang et al (2009) Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signaling. Cancer Res. 69 7986. PMID: 19826036.
Shankar et al (2008) EGCG inhibits growth, invasion, angiogenesis and metastastasis of pancreatic cancer. Front.Biosci. 13 440. PMID: 17981559.
Lee et al (2005) Mechanisms for the inhibition of DNA methyltransferases by tea catechins and bioflavonoids. Mol.Pharmacol. 68 1018. PMID: 16037419.
Jeon et al (2003) Green tea catechins as a BACE1 (β-secretase) inhibitor. Bioorg.Med.Chem.Lett. 13 3905. PMID: 14592472.
Ahmad et al (2000) Green tea polyphenol epigallocatechin-3-gallate differentially modulates nuclear factor κB in cancer cells versus normal cells. Ach.Biochem.Biophys. 376 338. PMID: 10775421.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for EGCG include:
Eom et al (2015) Synergistic effect of curcumin on epigallocatechin gallate-induced anticancer action in PC3 prostate cancer cells. Allergy Asthma Immunol Res 48 461. PMID: 25441423.
Do you know of a great paper that uses EGCG from Tocris? If so please let us know.
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Keywords: EGCG, supplier, BACE1, inhibitors, inhibits, β-secretase, b-secretase, beta-secretase, flavonoids, green, tea, antioxidants, neuroprotective, EGCG, epigallocatechin, gallate, amyloid, assembly, amyloidbeta, amyloidb, amyloidβ, glutamate, dehydrogenase, GDH, DNMT, DNA, Methyltransferases, Tocris Bioscience, Amyloid β Peptide Inhibitor products
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