Cat. No. 4523
Chemical Name: 4,4'-Diisothiocyanato-2,2'-stilbenedi
Biological ActivityClC-Ka chloride channel blocker (IC50 = 100 μM). Blocks the maxi chloride channel in apical membranes from human placenta. Displays antagonistic activity at TRPM4 and TRPC4 channels; potentiates agonist-induced TRPV1 currents (IC50 = 4.88 μM in rat DRG neurons). Inhibits RAD51 recombinase activity (KD = 2 μM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Zhang et al (2012) Agonist-dependent potentiation of vanilloid receptor transient receptor potential vanilloid type 1 function by stilbene derivatives. Mol.Pharmacol. 81 689. PMID: 22328719.
Ishida et al (2009) DIDS, a chemical compound that inhibits RAD51-mediated homologous pairing and strand exchange. Nucleic Acids Res. 37 3367. PMID: 19336413.
Wulff (2008) New light on the "old" chloride channel blocker DIDS. ACS Chem.Biol. 3 399. PMID: 18642798.
Riquelme and Parra et al (1999) Regulation of human placental chloride channel by arachidonic acid and other cis unsaturated fatty acids. Am.J.Obstet.Gynecol. 180 469. PMID: 9988821.
If you know of a relevant reference for DIDS please let us know.
Citations are publications that use Tocris products. Selected citations for DIDS include:
Cao et al (2014) SLC17A9 protein functions as a lysosomal ATP transporter and regulates cell viability. BMB Rep 289 23189. PMID: 24962569.
Harper and Poole (2013) Chloride channels are necessary for full platelet phosphatidylserine exposure and procoagulant activity. J Biol Chem 4 e969. PMID: 24357800.
Do you know of a great paper that uses DIDS from Tocris? If so please let us know.
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Keywords: DIDS, supplier, chloride, channels, ClC-Ka, blockers, trpm4, trpc4, transient, receptor, potential, vanilloid, receptors, trpv1, rad51, homologous, recombination, dna, damage, repair, double, strand, breaks, 4,4-Diisothiocyanato-2,2-stilbenedisulfonic, Tocris Bioscience, Other Chloride Channel Blocker products
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