Cat. No. 4521
Chemical Name: 3-[Bis(4-methoxyphenyl)methylene]-1
Biological ActivityInhibitor of smooth muscle cell migration and proliferation. Blocks voltage-independent calcium influx and downstream PKC signaling. Inhibits neointimal thickening after balloon catheter injury to the rat common carotid artery.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Sasaki et al (2000) TAS-301 blocks receptor-operated calcium influx and inhibits rat vascular smooth muscle cell proliferation induced by basic fibroblast growth factor and platelet-derived growth factor. Jpn.J.Pharmacol. 84 252. PMID: 11138725.
Muranaka et al (1998) TAS-301, an inhibitor of smooth muscle cell migration and proliferation, inhibits intimal thickening after balloon injury to rat carotid arteries. J.Pharmacol.Exp.Ther. 285 1280. PMID: 9618434.
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