TAS 301

Cat. No. 4521

TAS 301 C23H19NO3 [193620-69-8]

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Chemical Name: 3-[Bis(4-methoxyphenyl)methylene]-1,3-dihydro-2H-indol-2-one

Biological Activity

Inhibitor of smooth muscle cell migration and proliferation. Blocks voltage-independent calcium influx and downstream PKC signaling. Inhibits neointimal thickening after balloon catheter injury to the rat common carotid artery.

Technical Data

M.Wt:
357.4
Formula:
C23H19NO3
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
193620-69-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Sasaki et al (2000) TAS-301 blocks receptor-operated calcium influx and inhibits rat vascular smooth muscle cell proliferation induced by basic fibroblast growth factor and platelet-derived growth factor. Jpn.J.Pharmacol. 84 252. PMID: 11138725.

Muranaka et al (1998) TAS-301, an inhibitor of smooth muscle cell migration and proliferation, inhibits intimal thickening after balloon injury to rat carotid arteries. J.Pharmacol.Exp.Ther. 285 1280. PMID: 9618434.

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Citations are publications that use Tocris products.

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Keywords: TAS 301, supplier, TAS301, smooth, muscles, cells, migration, proliferation, blockers, inhibitors, inhibits, voltage-independent, calcium, influx, neointimal, thickening, stenosis, angioplasty, restenosis, Tocris Bioscience, Miscellaneous Compound products

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