TAS 301

Cat. No. 4521

TAS 301 C23H19NO3 [193620-69-8]

Price and Availability

For TAS 301 pricing & availability please select your country from the drop down menu:
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 3-[Bis(4-methoxyphenyl)methylene]-1,3-dihydro-2H-indol-2-one

Biological Activity

Inhibitor of smooth muscle cell migration and proliferation. Blocks voltage-independent calcium influx and downstream PKC signaling. Inhibits neointimal thickening after balloon catheter injury to the rat common carotid artery.

Technical Data

Soluble to 100 mM in DMSO
>99 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Sasaki et al (2000) TAS-301 blocks receptor-operated calcium influx and inhibits rat vascular smooth muscle cell proliferation induced by basic fibroblast growth factor and platelet-derived growth factor. Jpn.J.Pharmacol. 84 252. PMID: 11138725.

Muranaka et al (1998) TAS-301, an inhibitor of smooth muscle cell migration and proliferation, inhibits intimal thickening after balloon injury to rat carotid arteries. J.Pharmacol.Exp.Ther. 285 1280. PMID: 9618434.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses TAS 301 from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: TAS 301, supplier, TAS301, smooth, muscles, cells, migration, proliferation, blockers, inhibitors, inhibits, voltage-independent, calcium, influx, neointimal, thickening, stenosis, angioplasty, restenosis, Tocris Bioscience, Miscellaneous Compound products

Quick Order

Find multiple products by catalog number

divider line

New Product Guide

New Product Guide (Spring/Summer 2016)

Our New Product guide highlights over 110 new products added in the first half of 2016. View PDF today.

divider line

New Products in this Area


Antioxidant vitamin E derivative

NBD 556

CD4 mimetic; blocks HIV-1 cell entry

Sign-up for new product e-alerts
divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.