Cat. No. 4520
Alternative Name: Cytosine b-D-arabinofuranoside
Chemical Name: 4-Amino-1-β-D-arabinofuranosyl-2(1H)
Biological ActivityNucleoside analog of deoxycytidine; inhibits DNA replication by incorporating into DNA (IC50 = 0.04 μM in L1210 and CEM cell lines). Displays no inhibitory effects on RNA synthesis. Causes S phase cell cycle arrest in ML-1 cell lines; cytotoxic in L5817Y leukemia cells. Antineoplastic and antileukemic agent.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Sampath et al (2006) Pharmacodynamics of cytarabine alone and in combination with 7-hydroxystaurosporine (UCN-01) in AML blasts in vitro and during a clinical trial. Blood. 107 2517. PMID: 16293603.
Breistøl et al (1999) Antitumor activity of P-4055 (elaidic acid-cytarabine) compared to cytarabine in metastatic and s.c. human tumor xenograft models. Cancer Res. 59 2944. PMID: 10383159.
Yang et al (1986) Effect of cytarabine upon metabolism of phospholipids in leukemia L5178Y cells. Acta Pharmacol. Sin. 7 368. PMID: 2954403.
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Citations are publications that use Tocris products.
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