ML 213

Cat. No. 4519

ML 213 C17H23NO [489402-47-3]

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Chemical Name: N-(2,4,6-Trimethylphenyl)-bicyclo[2.2.1]heptane-2-carboxamide

Biological Activity

Selective KV7.2 (KCNQ2) and KV7.4 (KCNQ4) channel opener (EC50 values are 230 and 510 nM for KV7.2 and KV7.4 respectively). Displays > 80-fold selectivity against KV7.1, KV7.3 and KV7.5 in a thallium-based fluorescence assay.

Technical Data

M.Wt:
257.37
Formula:
C17H23NO
Solubility:
Soluble to 50 mM in DMSO and to 50 mM in ethanol
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
489402-47-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Yu et al (2011) Discovery, synthesis, and structure activity relationship of a series of N-aryl-bicyclo[2.2.1]heptane-2-carboxamides: Characterization of ML213 as a novel KCNQ2 and KCNQ4 potassium channel opener. ACS Chem.Neurosci. 2 572. PMID: 22125664.

If you know of a relevant reference for ML 213 please let us know.

Citations are publications that use Tocris products. Selected citations for ML 213 include:

Brueggemann et al (2014) Differential activation of vascular smooth muscle Kv7.4, Kv7.5, and Kv7.4/7.5 channels by ML213 and ICA-069673. Mol.Pharmacol. 86 330. PMID: 24944189.

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Keywords: ML 213, supplier, ML213, KCNQ2, KCNQ4, channels, openers, kv7.2, kv7.4, potassium, K+, voltage, gated, potassium, Kv, Tocris Bioscience, Voltage-gated Potassium (KV) Channel Activator products

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