NS 2028

Cat. No. 4517

NS 2028 C9H5BrN2O3 [204326-43-2]

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Chemical Name: 8-Bromo-1H,4H-[1,2,4]oxadiazolo[3,4-c][1,4]benzoxazin-1-one

Biological Activity

Potent soluble guanylyl cyclase (sGC) inhibitor (Ki = 8 nM). Blocks sGC activity in murine cerebellum induced by S-nitroso-glutathione and NMDA (IC50 values are 17 and 20 nM respectively). Inhibits VEGF-induced cGMP accumulation; abolishes VEGF-induced migration in postcapillary venular endothelial cells (CVEC).

Technical Data

Soluble to 100 mM in DMSO and to 20 mM in ethanol
>98 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Morbidelli et al (2010) The soluble guanylyl cyclase inhibitor NS-2028 reduces vascular endothelial growth factor-induced angiogenesis and permeability. Am.J.Physiol.Regul.Integr.Comp.Physiol. 298 R824. PMID: 20032260.

von Wantoch Rekowski et al (2010) Synthesis and biological evaluation of oxadiazole derivatives as inhibitors of soluble guanylyl cyclase. Bioorg.Med.Chem. 18 1288. PMID: 20036129.

Olesen et al (1998) Characterization of NS 2028 as a specific inhibitor of soluble guanylyl cyclase. Br.J.Pharmacol. 123 299. PMID: 9489619.

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Citations are publications that use Tocris products.

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Keywords: NS 2028, supplier, NS2028, supplier, soluble, guanylyl, cyclase, sGC, cGMP, VEGF, inhibitors, inhibits, potent, antiproliferative, Tocris Bioscience, Guanylyl Cyclase Inhibitor products

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