Cat. No. 4517
Chemical Name: 8-Bromo-1H,4H-[1,2,4]oxadiazolo[3,4
Biological ActivityPotent soluble guanylyl cyclase (sGC) inhibitor (Ki = 8 nM). Blocks sGC activity in murine cerebellum induced by S-nitroso-glutathione and NMDA (IC50 values are 17 and 20 nM respectively). Inhibits VEGF-induced cGMP accumulation; abolishes VEGF-induced migration in postcapillary venular endothelial cells (CVEC).
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Morbidelli et al (2010) The soluble guanylyl cyclase inhibitor NS-2028 reduces vascular endothelial growth factor-induced angiogenesis and permeability. Am.J.Physiol.Regul.Integr.Comp.Physiol. 298 R824. PMID: 20032260.
von Wantoch Rekowski et al (2010) Synthesis and biological evaluation of oxadiazole derivatives as inhibitors of soluble guanylyl cyclase. Bioorg.Med.Chem. 18 1288. PMID: 20036129.
Olesen et al (1998) Characterization of NS 2028 as a specific inhibitor of soluble guanylyl cyclase. Br.J.Pharmacol. 123 299. PMID: 9489619.
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Keywords: NS 2028, supplier, NS2028, supplier, soluble, guanylyl, cyclase, sGC, cGMP, VEGF, inhibitors, inhibits, potent, antiproliferative, Tocris Bioscience, Guanylyl Cyclase Inhibitor products
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