UNC 926 hydrochloride
Cat. No. 4516
Chemical Name: (3-Bromophenyl)[4-(1-prrolidinyl)-1
Biological ActivityMethyl-lysine (Kme) reader domain inhibitor; binds to the MBT domain of the L3MBTL1 protein (Kd = 3.9 μM). Selectively inhibits the L3MBTL13XMBT-H4K20me1 interaction in a peptide pull down assay.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Herold et al (2012) Structure-activity relationships of methyl-lysine reader antagonists. Med.Chem.Comm 3 45.
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Keywords: UNC 926 hydrochloride, supplier, UNC926, Methyl-lysine, Kme, readers, antagonists, MBT, domains, L3MBTL1, histones, epigenetics, Tocris Bioscience, MBT Domain Inhibitor products
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