UNC 926 hydrochloride

Cat. No. 4516

UNC 926 hydrochloride C16H21BrN2O.HCl [1184136-10-4]

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Chemical Name: (3-Bromophenyl)[4-(1-prrolidinyl)-1-piperidinyl]methanone hydrochloride

Biological Activity

Methyl-lysine (Kme) reader domain inhibitor; binds to the MBT domain of the L3MBTL1 protein (Kd = 3.9 μM). Selectively inhibits the L3MBTL13XMBT-H4K20me1 interaction in a peptide pull down assay.

Technical Data

Soluble to 100 mM in water and to 100 mM in DMSO
>99 %
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Herold et al (2012) Structure-activity relationships of methyl-lysine reader antagonists. Med.Chem.Comm 3 45.

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Keywords: UNC 926 hydrochloride, supplier, UNC926, Methyl-lysine, Kme, readers, antagonists, MBT, domains, L3MBTL1, histones, epigenetics, Tocris Bioscience, MBT Domain Inhibitor products

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