MMF

Cat. No. 4511

MMF C5H6O4 [2756-87-8]

Price and Availability

For MMF pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Name: mono-Methyl fumarate

Chemical Name: 2(E)-Butenedioic acid 1-methyl ester

Biological Activity

Nuclear factor (erythroid-derived-2)-like 2 (Nrf2) pathway activator. Also exhibits agonist activity at GPR109A. Primary metabolite of DMF (Cat. No. 4512).

Technical Data

M.Wt:
130.1
Formula:
C5H6O4
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>99 %
Storage:
Store at RT
CAS No:
2756-87-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Sciacovelli et al (2016) Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition Nature 537 544. PMID: 27580029.

Scannevin et al (2012) Fumarates promote cytoprotection of central nervous system cells against oxidative stress via the nuclear factor (erythroid-derived 2)-like 2 pathway. J.Pharmacol.Exp.Ther. 341 274. PMID: 22267202.

Hanson et al (2010) Nicotinic acid- and monomethyl fumarate-induced flushing involves GPR109A expressed by keratinocytes and COX-2-dependent prostanoid formation in mice. J.Clin.Invest. 120 2910. PMID: 20664170.

Tang et al (2008) The psoriasis durg monomethylfumarate is a potent nicotinic receptor agonist. Biochem.Biophys.Res.Commun. 375 562. PMID: 18722346.

Rao & Mishra (1998) Antihepatotoxic activity of monomethyl fumarate isolated from Fumaria indica. J.Ethnopharmacol. 60 207. PMID: 9613834.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses MMF from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: MMF, supplier, monomethylfumarate, nuclear, factor, erythroid, derived, like, 2, pathway, Nrf2, activators, GPR109A, niacin, nicotinic, acid, receptors, agonists, metabolite, dimethylfumarate, DMF, Tocris Bioscience, Antioxidant products

Quick Order

Find multiple products by catalog number

divider line

New Product Guide

New Product Guide (Fall/Winter 2016)

Our New Product guide highlights over 100 new products added in the second half of 2016. Request copy or view PDF today.

divider line

New Products in this Area

Chaetoglobosin A

Antibiotic; selective apoptosis inducer of CLL cells

Trolox

Antioxidant vitamin E derivative

Sign-up for new product e-alerts
divider line

Bio-Techne Events

ASN 2017

ASN 2017

March 18 - 22, 2017

Little Rock, ARK, USA