Cat. No. 4511
Alternative Name: mono-Methyl fumarate
Chemical Name: 2(E)-Butenedioic acid 1-methyl ester
Biological ActivityNuclear factor (erythroid-derived-2)-like 2 (Nrf2) pathway activator. Also exhibits agonist activity at GPR109A. Primary metabolite of DMF (Cat. No. 4512).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Sciacovelli et al (2016) Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition Nature 537 544. PMID: 27580029.
Scannevin et al (2012) Fumarates promote cytoprotection of central nervous system cells against oxidative stress via the nuclear factor (erythroid-derived 2)-like 2 pathway. J.Pharmacol.Exp.Ther. 341 274. PMID: 22267202.
Hanson et al (2010) Nicotinic acid- and monomethyl fumarate-induced flushing involves GPR109A expressed by keratinocytes and COX-2-dependent prostanoid formation in mice. J.Clin.Invest. 120 2910. PMID: 20664170.
Tang et al (2008) The psoriasis durg monomethylfumarate is a potent nicotinic receptor agonist. Biochem.Biophys.Res.Commun. 375 562. PMID: 18722346.
Rao & Mishra (1998) Antihepatotoxic activity of monomethyl fumarate isolated from Fumaria indica. J.Ethnopharmacol. 60 207. PMID: 9613834.
If you know of a relevant reference for MMF please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses MMF from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: MMF, supplier, monomethylfumarate, nuclear, factor, erythroid, derived, like, 2, pathway, Nrf2, activators, GPR109A, niacin, nicotinic, acid, receptors, agonists, metabolite, dimethylfumarate, DMF, Tocris Bioscience, Antioxidant products
Find multiple products by catalog number
New Products in this Area
Antiviral; active against Zika, West Nile and dengue viruses25-Hydroxycholesterol
Antiviral; also α-crystallin (cryAB) chaperoneFilipin III
Polyene antibiotic; inhibits formation of pathological isoform of prion protein
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.