SHA 68

Cat. No. 4510

SHA 68 C26H24FN3O3 [847553-89-3]

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Chemical Name: N-[(4-Fluorophenyl)methyl]tetrahydro-3-oxo-1,1-diphenyl-3H-oxazolo[3,4-a]pyrazine-7(1H)-carboxamide

Biological Activity

Selective neuropeptide S receptor (NPSR) antagonist (IC50 values are 22.0 and 23.8 nM for human NPSR Asn107 and Ile107 variants respectively). Displays no activity against a range of 14 GPCRs, including vasopressin and oxytocin receptors.

Technical Data

M.Wt:
445.49
Formula:
C26H24FN3O3
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
847553-89-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Okamura et al (2011) Neuropeptide S enhances memory during the consolidation phase and interacts with noradrenergic systems in the brain. Neuropsychopharmacology 36 744. PMID: 21150909.

Trapella et al (2011) Synthesis and separation of the enantiomers of the neuropeptide S receptor antagonist (9R/S)-3-oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4a]pyrazine-7-carboxylic acid 4-fluoro-benzylamide (SHA 68). J.Med.Chem. 54 2738. PMID: 21466221.

Okamura et al (2008) Synthesis and pharmacological in vitro and in vivo profile of 3-oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-a]pyrazine-7-carboxylic acid 4-fluoro-benzylamide (SHA 68), a selective antagonist of the neuropeptide S receptor. J.Pharmacol.Exp.Ther. 325 893. PMID: 18337476.

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Keywords: SHA 68, supplier, SHA68, neuropeptides, S, NPSRs, NPS, antagonists, selective, Tocris Bioscience, Other Peptide Receptor products

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