S 32212 hydrochloride

Cat. No. 4508

S 32212 hydrochloride C25H28N4O2.HCl [847871-78-7]

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Chemical Name: 1,2-Dihydro-N-[4-methoxy-3-(4-methyl-1-piperazinyl)phenyl]-3H-benz[e]indole-3-carboxamide hydrochloride

Biological Activity

Inverse agonist of 5-HT2C receptors (pKi = 8.18 at human 5-HT2C INI receptors). Also an antagonist of human α2-adrenoceptors. Displays negligible affinity for α1A-adrenoceptors, histamine H1 receptors and muscarinic M1 receptors.

Technical Data

M.Wt:
452.98
Formula:
C25H28N4O2.HCl
Solubility:
Soluble to 25 mM in water and to 25 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
847871-78-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Dekeyne et al (2012) S32212, a novel serotonin type 2C receptor inverse agonist/α2-adrenoceptor antagonist and potential antidepressant: II. A behavioral, neurochemical, and electrophysiological characterization. J.Pharmacol.Exp.Ther. 340 765. PMID: 22178753.

Millan et al (2012) S32212, a novel serotonin type 2C receptor inverse agonist/α2-adrenoceptor antagonist and potential antidepressant: I. A mechanistic characterization. J.Pharmacol.Exp.Ther. 340 750. PMID: 22178752.

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Keywords: S 32212 hydrochloride, supplier, S32212, antidepressants, 5-HT2C, inverse, agonists, serotonergic, alpha2, a2, α2, adrenergics, receptors, adrenoceptors, antagonists, Tocris Bioscience, 5-HT2C Receptor Antagonist products

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