S 32212 hydrochloride
Cat. No. 4508
Chemical Name: 1,2-Dihydro-N-[4-methoxy-3-(4-methy
Biological ActivityInverse agonist of 5-HT2C receptors (pKi = 8.18 at human 5-HT2C INI receptors). Also an antagonist of human α2-adrenoceptors. Displays negligible affinity for α1A-adrenoceptors, histamine H1 receptors and muscarinic M1 receptors.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Dekeyne et al (2012) S32212, a novel serotonin type 2C receptor inverse agonist/α2-adrenoceptor antagonist and potential antidepressant: II. A behavioral, neurochemical, and electrophysiological characterization. J.Pharmacol.Exp.Ther. 340 765. PMID: 22178753.
Millan et al (2012) S32212, a novel serotonin type 2C receptor inverse agonist/α2-adrenoceptor antagonist and potential antidepressant: I. A mechanistic characterization. J.Pharmacol.Exp.Ther. 340 750. PMID: 22178752.
If you know of a relevant reference for S 32212 hydrochloride please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses S 32212 hydrochloride from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: S 32212 hydrochloride, supplier, S32212, antidepressants, 5-HT2C, inverse, agonists, serotonergic, alpha2, a2, α2, adrenergics, receptors, adrenoceptors, antagonists, Tocris Bioscience, 5-HT2C Receptor Antagonist products
Find multiple products by catalog number
June 14 - 17, 2017
Boston, MA, USA