ML 218 hydrochloride
Cat. No. 4507
Chemical Name: 3,5-Dichloro-N-[[(1α,5α,6-exo,6α)-3-(3
Biological ActivitySelective inhibitor of T-type calcium channels (IC50 values are 270 and 310 nM for Cav3.3 and Cav3.2 respectively in a patch EP assay). Decreases burst activity in STN neurons; reduces cataleptic behaviour in an in vivo rat model of Parkinson's disease. Displays no significant inhibition of L- or N-type calcium channels, Kir6 (KATP) or KV11.1 (hERG) potassium channels. Orally active.
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Certificate of Analysis / Product Datasheet / Safety Datasheet
Galvan et al (2016) Lack of antiparkinsonian effects of systemic injections of the specific T-type calcium channel blocker ML218 in MPTP-treated monkeys. ACS Chem.Neurosci. PMID: 27596273 .
Xiang et al (2011) The discovery and characterization of ML218: A novel, centrally active T-type calcium channel inhibitor with robust effects in STN neurons and in a rodent model of Parkinson's disease. ACS Chem.Neurosci. 2 730. PMID: 22368764.
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Citations are publications that use Tocris products. Selected citations for ML 218 hydrochloride include:
Galvan et al (2016) Lack of Antiparkinsonian Effects of Systemic Injections of the Specific T-type Calcium Channel Blocker ML218 in MPTP-Treated Monkeys ACS ChemicalNeuroscience. PMID: 27596273.
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Keywords: ML 218 hydrochloride, supplier, ML218, HCl, CID45115620, T-type, calcium, channels, CAV3.1, CAV3.2, CAV3.3, inhibitors, inhibits, selective, Tocris Bioscience, Voltage-gated Calcium Channel (CaV) Blocker products
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