Cat. No. 4506
Chemical Name: N2-[(4-Methylphenyl)sulfonyl]-L-arg
Biological ActivityCompetitive inhibitor of the ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C); promotes Cdc20 autoubiquitination. Inhibits cyclin proteolysis in mitotic Xenopus oocyte extracts (IC50 = 12 μM) and blocks cyclin degradation in interphase extract.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Zeng & King (2012) An APC/C inhibitor stabilizes cyclin B1 by prematurely terminating ubiquitination. Nat.Chem.Biol. 8 383. PMID: 22366722.
Zeng et al (2010) Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage. Cancer Cell. 18 382. PMID: 20951947.
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Citations are publications that use Tocris products. Selected citations for TAME hydrochloride include:
Coles et al (2015) KIF7 Controls the Proliferation of Cells of the Respiratory Airway through Distinct Microtubule Dependent Mechanisms. PLoS Genet 11 e1005525. PMID: 26439735.
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Keywords: TAME hydrochloride, supplier, ubiquitin, ligase, anaphase-promoting, complex/cyclosome, APC, inhibits, inhibitors, competitive, mitotic, arrest, cyclin, stabilization, TAME, hydrochloride, HCl, Tocris Bioscience, Ubiquitin E3 Ligase Inhibitor products
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