Cat. No. 4506
Chemical Name: N2-[(4-Methylphenyl)sulfonyl]-L-arg
Biological ActivityCompetitive inhibitor of the ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C); promotes Cdc20 autoubiquitination. Inhibits cyclin proteolysis in mitotic Xenopus oocyte extracts (IC50 = 12 μM) and blocks cyclin degradation in interphase extract.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Zeng & King (2012) An APC/C inhibitor stabilizes cyclin B1 by prematurely terminating ubiquitination. Nat.Chem.Biol. 8 383. PMID: 22366722.
Zeng et al (2010) Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage. Cancer Cell. 18 382. PMID: 20951947.
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Citations are publications that use Tocris products. Selected citations for TAME hydrochloride include:
Coles et al (2015) KIF7 Controls the Proliferation of Cells of the Respiratory Airway through Distinct Microtubule Dependent Mechanisms. PLoS Genet 11 e1005525. PMID: 26439735.
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