Cat. No. 4505
Chemical Name: (6S,9aS)-Hexahydro-6-[(4-hydroxyphe
Biological ActivityInhibitor of TCF/β-catenin-mediated transcription. Selectively inhibits β-catenin/CBP interaction; displays no effect on β-catenin/p300 interaction. Exhibits growth inhibitory effects in colon carcinoma cell lines (SW480 and HCT-116 cells); also displays efficacy in Min mouse and nude mouse SW620 xenograft models.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Zhou et al (2012) Interactions between β-catenin and transforming growth factor-β signaling pathways mediate epithelial-mesenchymal transition and are dependent on the transcriptional co-activator cAMP-response element-binding protein (CREB)-binding protein (CBP). J.Biol.Chem. 287 7026. PMID: 22241478.
De Sousa et al (2011) Targeting wnt signaling in colon cancer stem cells. Clin.Cancer Res. 17 647. PMID: 21159886.
Emami et al (2004) A small molecule inhibitor of β-catenin/CREB-binding protein transcription. Proc.Natl.Acad.Sci.USA 101 12682. PMID: 15314234.
If you know of a relevant reference for ICG 001 please let us know.
Citations are publications that use Tocris products. Selected citations for ICG 001 include:
Long et al (2016) Integrin signalling regulates the expansion of neuroepithelial progenitors and neurogenesis via Wnt7a and Decorin. J Clin Invest 7 10354. PMID: 26838601.
Boulter et al (2015) WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited. PLoS One 125 1269. PMID: 25689248.
Corbett et al (2015) Non-Canonical Wnt Predominates in Activated Rat Hepatic Stellate Cells, Influencing HSC Survival and Paracrine Stimulation of Kupffer Cells. J Immunol 10 e0142794. PMID: 26566235.
Do you know of a great paper that uses ICG 001 from Tocris? If so please let us know.
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