Cat. No. 4505
Chemical Name: (6S,9aS)-Hexahydro-6-[(4-hydroxyphe
Biological ActivityInhibitor of TCF/β-catenin-mediated transcription. Selectively inhibits β-catenin/CBP interaction; displays no effect on β-catenin/p300 interaction. Exhibits growth inhibitory effects in colon carcinoma cell lines (SW480 and HCT-116 cells); also displays efficacy in Min mouse and nude mouse SW620 xenograft models.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Zhou et al (2012) Interactions between β-catenin and transforming growth factor-β signaling pathways mediate epithelial-mesenchymal transition and are dependent on the transcriptional co-activator cAMP-response element-binding protein (CREB)-binding protein (CBP). J.Biol.Chem. 287 7026. PMID: 22241478.
De Sousa et al (2011) Targeting wnt signaling in colon cancer stem cells. Clin.Cancer Res. 17 647. PMID: 21159886.
Emami et al (2004) A small molecule inhibitor of β-catenin/CREB-binding protein transcription. Proc.Natl.Acad.Sci.USA 101 12682. PMID: 15314234.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses ICG 001 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: ICG 001, supplier, ICG001, inhibits, inhibitors, TCF, t, cell, factors, b-catenin, beta-catenin, β-catenin, signaling, signalling, selectively, Tocris Bioscience, β-catenin products
Find multiple products by catalog number
September 14, 2016