Cat. No. 4504
Chemical Name: (3S,3'S,5aR,5aR,10bR,10'bR,11aS,11'aS)
Biological ActivityHistone methyltransferase SUV39H1 inhibitor (IC50 = 0.8 μM). Induces apoptosis in myeloma cell lines in vitro; exhibits antiproliferative activity in a mouse myeloma model in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Cherblanc et al (2013) Chaetocin is a nonspecific inhibitor of histone lysine methyltransferases. Nat.Chem.Biol. 9 136. PMID: 23416387.
Greiner et al (2013) Reply to "Chaetocin is a nonspecific inhibitor of histone lysine methyltransferases". Nat.Chem.Biol. 9 137. PMID: 23416388.
Isham et al (2007) Chaetocin: a promising new antimyeloma agent with in vitro and in vivo activity mediated via imposition of oxidative stress. Blood 109 2579. PMID: 17090648.
Greiner et al (2005) Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9. Nat.Chem.Biol. 1 143. PMID: 16408017.
If you know of a relevant reference for Chaetocin please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses Chaetocin from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: Chaetocin, supplier, histone, lysine, methyltransferase, HMTase, SUV39H1, su(var)3-9, epigenetics, inhibits, inhibitors, antiproliferative, myeloma, selective, G9a, Tocris Bioscience, Lysine Methyltransferase Inhibitor products
Find multiple products by catalog number
New Products in this Area
Potent and selective SAM-competitive EZH2 inhibitorBRD 4770
G9a inhibitor and S-adenosyl methionine mimetic; cell permeableLys-CoA
Selective p300 inhibitorUNC 2399
Biotinylated UNC 1999 (Cat.No. 4904)PF 06726304 acetate
Highly potent and SAM-competitive EZH2 inhibitorGSK 591 dihydrochloride
Potent and selective PRMT5 inhibitorTP 064
Potent and selective PRMT 4 inhibitor
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.