Cat. No. 4503
Chemical Name: (2R,3S,4S)-5-[4-(3,5-Dichlorophenyl
Biological ActivityAllosteric inhibitor of human Cdc34. Inhibits hCdc34-mediated ubiquitination of p27Kip1 (IC50 = 1.72 μM). Exhibits selectivity for hCdc34 over Uba1, Ube2G1, UbcH7, UbcH5, Ube2N (Ubc13), Ube2R2, SMURF2, SspH1 and Rnf168.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Huang et al (2014) E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin. Nat.Chem.Biol. 10 156. PMID: 24316736.
Ceccarelli et al (2011) An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme. Cell 145 1075. PMID: 21683433.
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Keywords: CC 0651, supplier, CC0651, allosteric, inhibitors, inhibits, hCDC34, ubiquitination, selective, ubl, E2, conjugating, enzymes, Tocris Bioscience, Ubiquitin/Ubl E2 Conjugating Enzyme Inhibitor products
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