Cat. No. 4502
Alternative Name: 3,3-Diindolylmethane
Chemical Name: 3,3'-Methylenediindole
Biological ActivityActivator of Chk2 that causes G2/M cell cycle arrest in various cancer cell lines. Antiproliferative and inducer of apoptosis; promotes proteasomal degradation of Cdc25C and Cdk1. Inhibits phosphorylation of EGFR and downstream activation of ERK.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Kandala et al (2012) Blocking epidermal growth factor receptor activation by 3,3'-diindolylmethane suppresses ovarian tumor growth in vitro and in vivo. J.Pharmacol.Exp.Ther. 341 24. PMID: 22205686.
Shorey et al (2012) 3,3'-diindolylmethane induces G1 arrest and apoptosis in human acute T-cell lymphoblastic leukemia cells. PLoS One. 7 e34975. PMID: 22514694.
Kandala & Srivastava (2010) Activation of checkpoint kinase 2 by 3,3'-diindolylmethane is required for causing G2/M cell cycle arrest in human ovarian cancer cells. Mol.Pharmacol. 78 297. PMID: 20444961.
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Keywords: DIM, supplier, Chk2, checkpoint, kinase, 2, activators, antiproliferatives, anticancer, chemotherapeutics, epidermal, growth, factor, receptors, EGFR, inhibitors, inhibits, pro-apoptotic, apoptosis, inducers, 3,3-diindolylmethane, Tocris Bioscience, EGFR Inhibitor products