Cat. No. 4501
Chemical Name: 1-β-D-Ribofuranosyl-1H-1,2,4-triazol
Biological ActivityAntiviral guanosine ribonucleoside analog; misincorporated into mRNA by viral-dependent RNA polymerases. Binds to and redistributes mammalian eIF4E from the nucleus to the cytoplasm (Ki ~ 0.3 μM for the active metabolite, ribavirin triphosphate). Represses colony formation of primary AML-M5 progenitor cells (IC50 ~ 1 μM); reduces disease severity in acute myeloid leukemia (AML). Orally available.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Assouline et al (2009) Molecular targeting of the oncogene eIF4E in acute myeloid leukemia (AML): a proof-of-principle clinical trial with ribavirin. Blood 114 257. PMID: 19433856.
Kentsis et al (2004) Ribavirin suppresses eIF4E-mediated oncogenic transformation by physical mimicry of the 7-methyl guanosine mRNA cap. Proc.Natl.Acad.Sci.U.S.A. 101 18105. PMID: 15601771.
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Keywords: Ribavirin, supplier, broad, spectrum, antivirals, guanosine, ribonucleoside, analogues, analogs, mammalian, eIF4E, inhibits, inhibitors, translocation, cellular, redistribution, virazole, Tocris Bioscience, DNA, RNA and Protein Synthesis Inhibitor products