Cat. No. 4500

Cercosporamide C16H13NO7 [131436-22-1]

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Chemical Name: (9aS)-8-Acetyl-9,9a-dihydro-1,3,7-trihydroxy-9a-methyl-9-oxo-4-dibenzofurancaboxamide

Biological Activity

Potent inhibitor of MAP-kinase interacting kinase-2 (Mnk2) and JAK3 (IC50 values are 11, 31 and 116 nM for Mnk2, JAK3 and Mnk1 respectively). Blocks eIF4E phosphorylation; exhibits antiproliferative and proapoptotic activity in cancer cells in vitro. Also inhibits Pkc1. Orally bioavailable.

Technical Data

Soluble to 10 mM in DMSO
>96 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Hou et al (2012) Targeting Mnks for cancer therapy. Oncotarget 3 118. PMID: 22392765.

Konicek et al (2011) Therapeutic inhibition of MAP kinase interacting kinase blocks eukaryotic initiation factor 4E phosphorylation and suppresses outgrowth of experimental lung metastases. Cancer Res. 71 1849. PMID: 21233335.

Sussman et al (2004) Discovery of cercosporamide, a known antifungal natural product, as a selective Pkc1 kinase inhibitor through high-throughput screening. Eukaryot.Cell 3 932. PMID: 15302826.

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Keywords: Cercosporamide, supplier, antifungals, Mnk2, MKNK2, MAP-kinase, interacting, kinases, MKNK2, Jak3, inhibitors, inhibits, Tocris Bioscience, Mnk Inhibitor products

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