Cat. No. 4496
Chemical Name: 6,7-Dihydro-3-phenyl-2-(propylthio)
Biological ActivitySelective phosphodiesterase (PDE) 11 inhibitor (IC50 = 0.28 μM for PDE11; IC50 values are >100 μM for PDE1 - PDE10). Significantly elevates cAMP levels and cortisol production in H295R human adenocarcinoma cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Ceyhan et al (2012) Identification of biologically active PDE11-selective inhibitors using a yeast-based high-throughput screen. Chem.Biol. 19 155. PMID: 22284362.
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Citations are publications that use Tocris products. Selected citations for BC 11-38 include:
Lu and Sewer (2015) p54nrb/NONO regulates cyclic AMP-dependent glucocorticoid production by modulating phosphodiesterase mRNA splicing and degradation. J Biol Chem 35 1223. PMID: 25605330.
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Keywords: BC 11-38, supplier, BC11-38, phosphodiesterase, pde, 11, inhibitors, inhibits, selective, Tocris Bioscience, Phosphodiesterase Inhibitor products
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