Cat. No. 4496
Chemical Name: 6,7-Dihydro-3-phenyl-2-(propylthio)
Biological ActivitySelective phosphodiesterase (PDE) 11 inhibitor (IC50 = 0.28 μM for PDE11; IC50 values are >100 μM for PDE1 - PDE10). Significantly elevates cAMP levels and cortisol production in H295R human adenocarcinoma cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Ceyhan et al (2012) Identification of biologically active PDE11-selective inhibitors using a yeast-based high-throughput screen. Chem.Biol. 19 155. PMID: 22284362.
If you know of a relevant reference for BC 11-38 please let us know.
Citations are publications that use Tocris products. Selected citations for BC 11-38 include:
Lu and Sewer (2015) p54nrb/NONO regulates cyclic AMP-dependent glucocorticoid production by modulating phosphodiesterase mRNA splicing and degradation. J Biol Chem 35 1223. PMID: 25605330.
Do you know of a great paper that uses BC 11-38 from Tocris? If so please let us know.
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Keywords: BC 11-38, supplier, BC11-38, phosphodiesterase, pde, 11, inhibitors, inhibits, selective, Tocris Bioscience, Phosphodiesterase Inhibitor products
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