BC 11-38

Cat. No. 4496

BC 11-38 C15H16N2OS2 [686770-80-9]

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Chemical Name: 6,7-Dihydro-3-phenyl-2-(propylthio)thieno[3,2-d]pyrimidin-4(3H)one

Biological Activity

Selective phosphodiesterase (PDE) 11 inhibitor (IC50 = 0.28 μM for PDE11; IC50 values are >100 μM for PDE1 - PDE10). Significantly elevates cAMP levels and cortisol production in H295R human adenocarcinoma cells.

Technical Data

Soluble to 100 mM in DMSO and to 20 mM in ethanol
>98 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Ceyhan et al (2012) Identification of biologically active PDE11-selective inhibitors using a yeast-based high-throughput screen. Chem.Biol. 19 155. PMID: 22284362.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for BC 11-38 include:

Lu and Sewer (2015) p54nrb/NONO regulates cyclic AMP-dependent glucocorticoid production by modulating phosphodiesterase mRNA splicing and degradation. J Biol Chem 35 1223. PMID: 25605330.

Do you know of a great paper that uses BC 11-38 from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: BC 11-38, supplier, BC11-38, phosphodiesterase, pde, 11, inhibitors, inhibits, selective, Tocris Bioscience, Phosphodiesterase Inhibitor products

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