Flurizan

Cat. No. 4495

Flurizan C15H13FO2 [51543-40-9]

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Alternative Name: (R)-Flurbiprofen

Chemical Name: (R)-2-Fluoro-α-methyl[1,1'-biphenyl]-4-acetic acid

Biological Activity

Nonsteroidal anti-inflammatory drug (NSAID) that inhibits γ-secretase activity. Selectively lowers Aβ42 levels in human neuroglioma cells; displays no effect on Aβ40 levels at a concentration of 100 μM.

Technical Data

M.Wt:
244.26
Formula:
C15H13FO2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>99 %
Storage:
Store at RT
CAS No:
51543-40-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Kukar et al (2007) Chronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice. BMC Neurosci. 8 54. PMID: 17650315.

Eriksen et al (2003) NSAIDs and enantiomers of flurbiprofen target γ-secretase and lower Aβ42 in vivo. J.Clin.Invest. 112 440. PMID: 12897211.

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Citations are publications that use Tocris products.

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Keywords: Flurizan, supplier, NSAIDs, gamma, secretase, inhibitors, inhibits, AB42, beta, amyloid, flurbiprofen, tarenflurbil, R-flurbiprofen, Aβ42, and, Abeta42, gamma-secretase, amyloidbeta, amyloidb, amyloidβ, Tocris Bioscience, γ-Secretase Inhibitor products

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