Cat. No. 4495
Alternative Name: (R)-Flurbiprofen
Chemical Name: (R)-2-Fluoro-α-methyl[1,1'-biphenyl]-
Biological ActivityNonsteroidal anti-inflammatory drug (NSAID) that inhibits γ-secretase activity. Selectively lowers Aβ42 levels in human neuroglioma cells; displays no effect on Aβ40 levels at a concentration of 100 μM.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Kukar et al (2007) Chronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice. BMC Neurosci. 8 54. PMID: 17650315.
Eriksen et al (2003) NSAIDs and enantiomers of flurbiprofen target γ-secretase and lower Aβ42 in vivo. J.Clin.Invest. 112 440. PMID: 12897211.
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Keywords: Flurizan, supplier, NSAIDs, gamma, secretase, inhibitors, inhibits, AB42, beta, amyloid, flurbiprofen, tarenflurbil, R-flurbiprofen, Aβ42, and, Abeta42, gamma-secretase, amyloidbeta, amyloidb, amyloidβ, Tocris Bioscience, γ-Secretase Inhibitor products
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