(R)-DPN

Cat. No. 4494

(R)-DPN C15H13NO2 [524047-78-7]

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Chemical Name: (R)-2,3-bis(4-Hydroxyphenyl)-propionitrile

Biological Activity

Enantiomer of DPN (Cat. No. 1494). Displays higher affinity for estrogen receptor (ER) β over ERα (Ki values are 1.82 and 147 nM respectively).

Technical Data

M.Wt:
239.27
Formula:
C15H13NO2
Solubility:
Soluble to 25 mM in 1eq. NaOH and to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
524047-78-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Carroll et al (2011) Diarylpropionitrile (DPN) enantiomers: synthesis and evaluation of estrogen receptor β-selective ligands. J.Med.Chem. 55 528. PMID: 22122563.

Weiser et al (2009) Estrogen receptor-β agonist diarylpropionitrile: biological activities of R- and S-enantiomers on behavior and hormonal response to stress. Endocrinology 150 1817. PMID: 19074580.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for (R)-DPN include:

Murata et al (2014) Rat uterine oxytocin receptor and estrogen receptor α and β mRNA levels are regulated by estrogen through multiple estrogen receptors. Mol Cell Biol 60 55. PMID: 24334513.

Do you know of a great paper that uses (R)-DPN from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: (R)-DPN, supplier, enantiomer, DPN, diarylpropionitrile, estrogen, receptors, ERbeta, ERb, ERβ, Tocris Bioscience, Estrogen and Related Receptor Agonist products

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