Cat. No. 4493

Paliperidone C23H27FN4O3 [144598-75-4]

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Alternative Names: 9-Hydroxyrisperidone, 9-OH-risperidone

Chemical Name: 3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one

Biological Activity

Atypical antipsychotic; metabolite of risperidone (Cat. No. 2865). Exhibits high affinity for 5-HT2A receptors (Ki = 0.4 nM for cloned human 5-HT2A receptors). Also displays nanomolar affinity for human D2 receptors.

Technical Data

Soluble to 10 mM in DMSO
>98 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Dremencov et al (2007) Distinct electrophysiological effects of paliperidone and risperidone on the firing activity of rat serotonin and norepinephrine neurons. Psychopharmacology 194 63. PMID: 17530476.

Schotte et al (1996) Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding. Psychopharmacology 124 57. PMID: 8935801.

Leysen et al (1994) Risperidone: a novel antipsychotic with balanced serotonin-dopamine antagonism, receptor occupancy profile, and pharmacologic activity. J.Clin.Psychiatry 55 5. PMID: 7520908.

Megens and Awouters et al (1994) In vivo pharmacological profile of 9-hydroxyrisperidone, the major metabolite of the novel antipsychotic risperidone. 33 399.

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Keywords: Paliperidone, supplier, atypical, antipsychotic, 5-ht2a, serotonergic, serotonin, antagonists, dopamine, dopaminergic, d2, high, affinity, 9-OH-risperidone, 9-hydroxyrisperidone, Tocris Bioscience, 5-HT2A Receptor Antagonist products

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