Cat. No. 4492
Alternative Name: CNS 1102
Chemical Name: N-(3-Ethylphenyl)-N-methyl-N'-1-naph
Biological ActivityPotent and noncompetitive NMDA receptor antagonist (IC50 = 36 nM). Exhibits >70-fold selectivity for NMDA receptor over σ receptor. Neuroprotective in a rat model of focal ischemia.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Schäbitz et al (2000) The N-methyl-D-aspartate antagonist CNS 1102 protects cerebral gray and white matter from ischemic injury following temporary focal ischemia in rats. Stroke 31 1709. PMID: 10884477.
Reddy et al (1994) Synthesis and structure-activity studies of N,N'-diarylguanidine derivatives. N-(1-naphthyl)-N'-(3-ethylphenyl)-N'-methylguanidine: a new, selective noncompetitive NMDA receptor antagonist. J.Med.Chem. 37 260. PMID: 8295213.
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Keywords: Cerestat, supplier, CNS1102, potent, noncompetitive, NMDA, receptors, antagonists, selective, neuroprotection, neuroprotective, ischemia, stroke, Tocris Bioscience, NMDA Receptor Antagonist products
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