DQP 1105

Cat. No. 4491

DQP 1105 C29H24BrN3O4 [380560-89-4]

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Chemical Name: 5-(4-Bromophenyl)-3-(1,2-dihydro-6-methyl-2-oxo-4-phenyl-3-quinolinyl)-4,5-dihydro-γ-oxo-1H-pyrazole-1-butanoic acid

Biological Activity

Noncompetitive NMDA receptor antagonist; displays over 50-fold selectivity for GluN2D- and GluN2C-containing receptors over GluN2B-, GluK2-, GluA1- and GluN2A-containing receptors (IC50 values are 2.7, 8.5, 121, 153, 198 and 206 μM, respectively). Reduces frequency of channel opening.

Technical Data

M.Wt:
558.42
Formula:
C29H24BrN3O4
Solubility:
Soluble to 100 mM in DMSO
Purity:
>97 %
Storage:
Store at -20°C
CAS No:
380560-89-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Acker et al (2011) Mechanism for noncompetitive inhibition by novel GluN2C/D N-methyl-D-aspartate receptor subunit-selective modulators. Mol.Pharmacol. 80 782. PMID: 21807990.

If you know of a relevant reference for DQP 1105 please let us know.

Citations are publications that use Tocris products. Selected citations for DQP 1105 include:

Lozovaya et al (2014) Selective suppression of excessive GluN2C expression rescues early epilepsy in a tuberous sclerosis murine model. Nat Commun 5 4563. PMID: 25081057.

Do you know of a great paper that uses DQP 1105 from Tocris? If so please let us know.

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Keywords: DQP 1105, supplier, DQP1105, supplier, NMDAD, NMDAD, Glu2NC, Glu2NC, antagonists, selective, noncompetitive, inhibitors, inhibits, Tocris Bioscience, NMDA Receptor Antagonist products

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