Cat. No. 4490

Alantolactone C15H20O2 [546-43-0]

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Chemical Name: (3aR,5S,8aR,9aR)-3a,5,6,7,8,8a,9,9a-Octahydro-5,8a-dimethyl-3-methylenenaphtho[2,3-b]furan-2(3H)-one

Biological Activity

Sesquiterpene lactone. Induces activin/SMAD3 signaling and disrupts Cripto-1/activin receptor type II A interaction. Displays antiproliferative activity in human colon adenocarcinoma HCT-8 cells.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in ethanol
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Shi et al (2011) Alantolactone inhibits cell proliferation by interrupting the interaction between Cripto-1 and activin receptor type II A in activin signaling pathway. J.Biomol.Screen. 16 525. PMID: 21378277.

Pal et al (2010) Activation of caspases and poly (ADP-ribose) polymerase cleavage to induce apoptosis in leukemia HL-60 cellsby Inula racemosa. Toxicol.In Vitro. 24 1599. PMID: 20600805.

Dupuis & Brisson et al (1976) Toxic effect of alantolactone and dihydroalantolactone in in vitro cultures of leukocytes. Chem.Biol.Interact. 15 205. PMID: 1000726.

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Keywords: Alantolactone, supplier, antiproliferative, sesquiterpene, lactones, activin, SMAD3, type, II, A, receptors, Tocris Bioscience, BMP and Other Activin Receptor products

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