Cat. No. 4490
Chemical Name: (3aR,5S,8aR,9aR)-3a,5,6,7,8,8a,9,9a
Biological ActivitySesquiterpene lactone. Induces activin/SMAD3 signaling and disrupts Cripto-1/activin receptor type II A interaction. Displays antiproliferative activity in human colon adenocarcinoma HCT-8 cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Shi et al (2011) Alantolactone inhibits cell proliferation by interrupting the interaction between Cripto-1 and activin receptor type II A in activin signaling pathway. J.Biomol.Screen. 16 525. PMID: 21378277.
Pal et al (2010) Activation of caspases and poly (ADP-ribose) polymerase cleavage to induce apoptosis in leukemia HL-60 cellsby Inula racemosa. Toxicol.In Vitro. 24 1599. PMID: 20600805.
Dupuis & Brisson et al (1976) Toxic effect of alantolactone and dihydroalantolactone in in vitro cultures of leukocytes. Chem.Biol.Interact. 15 205. PMID: 1000726.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses Alantolactone from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Alantolactone, supplier, antiproliferative, sesquiterpene, lactones, activin, SMAD3, type, II, A, receptors, Tocris Bioscience, BMP and Other Activin Receptor products
Find multiple products by catalog number
New Products in this Area
Potent and selective ALK2 and ALK3 inhibitor; promotes neural induction of hPSCs
Follow Tocris on LinkedIn
Visit our LinkedIn page for the latest Tocris news, events and updates.