Cat. No. 4488
Chemical Name: 3-β-D-Ribofuranosyl-3H-imidazo[4,5-b
Biological ActivityInhibitor of adenosine deaminase (Ki = 0.66 μM). Demonstrates antitumor activity in a range of leukemia cell lines.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Cristalli et al (1993) Adenosine deaminase inhibitors: Structure-activity relationships in 1-deazaadenosine and erythro-9-(2-hydroxy-3-nonyl)adenine analogues. Drug Dev.Res. 28 253.
Cristalli et al (1987) Improved synthesis and antitumor activity of 1-deazaadenosine. J.Med.Chem. 30 1686. PMID: 3625714.
If you know of a relevant reference for 1-Deazaadenosine please let us know.
Citations are publications that use Tocris products. Selected citations for 1-Deazaadenosine include:
Li et al (2015) Inhibition of adenosine deaminase (ADA)-mediated metabolism of cordycepin by natural substances. Anticancer Res 3 e00121. PMID: 26038697.
Do you know of a great paper that uses 1-Deazaadenosine from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: 1-Deazaadenosine, supplier, inhibitors, inhibits, adenosine, deaminase, Tocris Bioscience, Deaminase Inhibitor products
Find multiple products by catalog number
New Products in this Area
Fluorometric CYP450 substrateGaleterone
CYP17 inhibitor; also androgen receptor antagonistPF 04449613
Potent PDE9 inhibitor; brain penetrant
Follow Tocris on LinkedIn
Visit our LinkedIn page for the latest Tocris news, events and updates.