1-Deazaadenosine

Cat. No. 4488

1-Deazaadenosine C11H14N4O4 [14432-09-8]

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Chemical Name: 3-β-D-Ribofuranosyl-3H-imidazo[4,5-b]pyridin-7-amine

Biological Activity

Inhibitor of adenosine deaminase (Ki = 0.66 μM). Demonstrates antitumor activity in a range of leukemia cell lines.

Technical Data

M.Wt:
266.25
Formula:
C11H14N4O4
Solubility:
Soluble to 25 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
14432-09-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Cristalli et al (1993) Adenosine deaminase inhibitors: Structure-activity relationships in 1-deazaadenosine and erythro-9-(2-hydroxy-3-nonyl)adenine analogues. Drug Dev.Res. 28 253.

Cristalli et al (1987) Improved synthesis and antitumor activity of 1-deazaadenosine. J.Med.Chem. 30 1686. PMID: 3625714.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for 1-Deazaadenosine include:

Li et al (2015) Inhibition of adenosine deaminase (ADA)-mediated metabolism of cordycepin by natural substances. Anticancer Res 3 e00121. PMID: 26038697.

Do you know of a great paper that uses 1-Deazaadenosine from Tocris? If so please let us know.

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Keywords: 1-Deazaadenosine, supplier, inhibitors, inhibits, adenosine, deaminase, Tocris Bioscience, Deaminase Inhibitor products

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