Cat. No. 4487
Chemical Name: N-1-[(3-4(-Ethoxyphenyl)-3,4-dihydr
Biological ActivityAntagonist of CXCR3; inhibits binding of 125I-IP-10 and 125I-ITAC to CXCR3 (IC50 values are 8.0 and 8.2 nM respectively). Inhibits CXCR3-mediated cell migration by the chemokines IP-10, ITAC and MiG in vitro (IC50 values are 8, 15 and 36 nM respectively). Also shown to inhibit lung metastasis in a mouse model of metastatic breast cancer.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Cambien et al (2009) Organ-specific inhibition of metastatic colon carcinoma by CXCR3 antagonism. Br.J.Cancer 100 1755. PMID: 19436305.
Johnson et al (2007) Discovery and optimization of a series of quinazolinone-derived antagonists of CXCR3. Bioorg.Med.Chem.Lett. 17 3339. PMID: 17448658.
Walser et al (2006) Antagonism of CXCR3 inhibits lung metastasis in a murine model of metastatic breast cancer. Cancer Res. 66 7701. PMID: 16885372.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses (±)-AMG 487 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: (±)-AMG 487, supplier, CXCR3, chemokine, receptors, antagonists, inhibitors, inhibits, cell, migration, metastasis, ±-AMG487, ±-AMG_487, Tocris Bioscience, Chemokine CXC Receptor Antagonist products
Find multiple products by catalog number
New Products in this Area
Potent CXCR2 antagonist
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.