Cat. No. 4486
Chemical Name: Phenylmethylsulfonyl fluoride
Biological ActivityNon-selective protease inhibitor; irreversibly sulfonates key active site serine residues in serine proteases, acetylcholinesterases, and thiol proteases. Blocks metabolism of anandamide (Cat. No. 1339) in a rodent model of cannabimimetic activity. Unstable in water (t1/2 ~ 60 mins at pH 7.5). Brain penetrant.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Day et al (2001) Role of fatty acid amide hydrolase in the transport of the endogenous cannabinoid anandamide. Mol.Pharmacol. 59 1369. PMID: 11353795.
Compton & Martin (1997) The effect of the enzyme inhibitor phenylmethylsulfonyl fluoride on the pharmacological effect of anandamide in the mouse model of cannabimimetic activity. J.Pharmacol.Exp.Ther. 283 1138. PMID: 9399986.
Turini et al (1969) The action of phenylmethylsulfonyl fluoride on human acetylcholinesterase, chymotrypsin and trypsin. J.Pharmacol.Exp.Ther. 167 98. PMID: 4306345.
If you know of a relevant reference for PMSF please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses PMSF from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: PMSF, supplier, proteases, inhibits, inhibitors, irreversible, sulfonation, brain, penetrant, FAAH, anandamide, fatty, acid, amide, hydrolase, Tocris Bioscience, Other Protease Inhibitor products
Find multiple products by catalog number
New Products in this Area
Plasminogen activator inhibitor-1 (PAI-1) inhibitorSB 3CT
Selective high affinity MMP2 inhibitor
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.