Cat. No. 4484
Chemical Name: 4-[[[[4-(1,1-Dimethylethyl)phenyl]s
Biological ActivityInhibitor of GLUT1; inhibits glucose uptake in renal cell carcinoma (RCC) 4 cells. Activity causes necrotic cell death in von Hippel-Lindau (VHL)-deficient RCC cells. Also NAMPT inhibitor. Eliminates human pluripotent stem cells from culture with limited toxicity towards differentiated cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Kropp et al (2015) Inhibition of an NAD+ salvage pathway provides efficient and selective toxicity to human pluripotent stem cells. Stem Cells Transl.Med. 4 483. PMID: 25834119.
Adams et al (2014) NAMPT is the cellular target of STF-31-like small-molecule probes. ACS Chem.Biol. 9 2247. PMID: 25058389.
Chan et al (2011) Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality. Sci.Transl.Med. 3 94ra70. PMID: 21813754.
If you know of a relevant reference for STF 31 please let us know.
Citations are publications that use Tocris products. Selected citations for STF 31 include:
Kropp et al (2015) Inhibition of an NAD+ salvage pathway provides efficient and selective toxicity to human pluripotent stem cells. Mol Cell Biol 4 483. PMID: 25834119.
Do you know of a great paper that uses STF 31 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: STF 31, supplier, STF31, glut1, glucose, transporters, inhibitors, inhibits, glucose, uptake, slc2a1, Tocris Bioscience, NAMPT Inhibitor products
Find multiple products by catalog number
New Products in this Area
Potent and selective SAM-competitive EZH2 inhibitorBRD 4770
G9a inhibitor and S-adenosyl methionine mimetic; cell permeableLys-CoA
Selective p300 inhibitorUNC 2399
Biotinylated UNC 1999 (Cat.No. 4904)PF 06726304 acetate
Highly potent and SAM-competitive EZH2 inhibitorGSK 591 dihydrochloride
Potent and selective PRMT5 inhibitorTP 064
Potent and selective PRMT 4 inhibitor
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.