Cat. No. 4484
Chemical Name: 4-[[[[4-(1,1-Dimethylethyl)phenyl]s
Biological ActivityInhibitor of GLUT1; inhibits glucose uptake in renal cell carcinoma (RCC) 4 cells. Activity causes necrotic cell death in von Hippel-Lindau (VHL)-deficient RCC cells. Also NAMPT inhibitor. Eliminates human pluripotent stem cells from culture with limited toxicity towards differentiated cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Kropp et al (2015) Inhibition of an NAD+ salvage pathway provides efficient and selective toxicity to human pluripotent stem cells. Stem Cells Transl.Med. 4 483. PMID: 25834119.
Adams et al (2014) NAMPT is the cellular target of STF-31-like small-molecule probes. ACS Chem.Biol. 9 2247. PMID: 25058389.
Chan et al (2011) Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality. Sci.Transl.Med. 3 94ra70. PMID: 21813754.
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Citations are publications that use Tocris products. Selected citations for STF 31 include:
Kropp et al (2015) Inhibition of an NAD+ salvage pathway provides efficient and selective toxicity to human pluripotent stem cells. Mol Cell Biol 4 483. PMID: 25834119.
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Keywords: STF 31, supplier, STF31, glut1, glucose, transporters, inhibitors, inhibits, glucose, uptake, slc2a1, Tocris Bioscience, NAMPT Inhibitor products
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