Cat. No. 4483
Chemical Name: 7-Amino-1-cyclopropyl-3-ethyl-1,2,3
Biological ActivityInhibitor of eukaryotic elongation factor-2 (eEF-2) kinase (IC50 = 0.28 μM in enzymatic assay). Reduces eEF-2 phosphorylation with little effect on cancer cell growth.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Chen et al (2011) 1-Benzyl-3-cetyl-2-methylimidazolium iodide (NH125) induces phosphorylation of eukaryotic elongation factor-2 (eEF2): a cautionary note on the anticancer mechanism of an eEF2 kinase inhibitor. J.Biol.Chem. 286 43951. PMID: 22020937.
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Keywords: A 484954, supplier, A484954, eukaryotic, elongation, factor-2, kinase, eef2k, inhibitors, inhibits, Tocris Bioscience, Calmodulin-Dependent Kinase Inhibitor products
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