PR 619

Cat. No. 4482

PR 619 C7H5N5S2 [2645-32-1]

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Chemical Name: 2,6-Diamino-3,5-dithiocyanopyridine

Biological Activity

Broad spectrum, reversible DUB inhibitor. Exhibits limited activity against other proteases. Induces accumulation of polyubiquitinated proteins, but has no direct inhibitory effect on the proteasome. Cytotoxic in HEK293T and colorectal cancer cells. Stabilizes microtubule network in oligodendroglial cells.

Technical Data

Soluble to 10 mM in DMSO
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Seiberlich et al (2012) The small molecule inhibitor PR-619 of deubiquitinating enzymes affects the microtubule network and causes protein aggregate formation in neural cells: implications for neurodegenerative diseases. Biochim.Biophys.Acta 1823 2057. PMID: 22565157.

Altun et al (2011) Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes. Chem.Biol. 18 1401. PMID: 22118674.

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Keywords: PR 619, supplier, PR619, inhibitors, DUBs, deubiquitinating, enzymes, deubiquitination, proteasome, inhibits, broad, spectrum, proteases, Tocris Bioscience, Deubiquitinating Enzyme Inhibitor products

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