4μ8C

Cat. No. 4479

4mu8C C11H8O4 [14003-96-4]

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Chemical Name: 7-Hydroxy-4-methyl-2-oxo-2H-1-benzopyran-8-carboxaldehyde

Biological Activity

Selective inhibitor of IRE1α ribonuclease (RNase) activity (IC50 = 60 nM). Blocks substrate access to the active site of IRE1α. Inactivates IRE1α-mediated mRNA degradation. Displays no effect on the IRE1α-related endoribonuclease RNase L.

Technical Data

M.Wt:
204.18
Formula:
C11H8O4
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
14003-96-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Cross et al (2012) The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule. Proc.Natl.Acad.Sci.USA 109 E869. PMID: 22315414.

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Keywords: 4mu8C, supplier, 4m8C, 4mu8C, 4μ8C, selective, inhibitors, inhibits, ire1, rnase, endoribonuclease, Tocris Bioscience, IRE1 Inhibitor products

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