Cat. No. 4478

GPBAR-A C23H15F7N2O2 [877052-79-4]

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Chemical Name: 4-[[3,5-Bis(trifluoromethyl)phenyl]methyl]-6-(2-fluorophenyl)-4,5-dihydro-pyrido[3,2-f]-1,4-oxazepin-3(2H)-one

Biological Activity

GPBA receptor agonist. Upregulates GLP-1 secretion from intestinal cultures. Increases MQAE-fluorescence suggesting a decrease in intracellular chloride concentration in gallbladder epithelial cells.

Technical Data

Soluble to 100 mM in DMSO and to 20 mM in ethanol
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Parker et al (2012) Molecular mechanisms underlying bile acid-stimulated glucagon-like peptide-1 secretion. Br.J.Pharmacol. 165 414. PMID: 21718300.

Keitel et al (2009) The membrane-bound bile acid receptor TGR5 is localized in the epithelium of human gallbladders. Hepatology 50 861. PMID: 19582812.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for GPBAR-A include:

Kowal et al (2015) Bile acid effects are mediated by ATP release and purinergic signalling in exocrine pancreatic cells. Stem Cells Transl Med 13 28. PMID: 26050734.

Do you know of a great paper that uses GPBAR-A from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: GPBAR-A, supplier, TGR5, agonists, g-protein, bile, acid, receptors, GPBA, GPBAR, Tocris Bioscience, GPBA Receptor Agonist products

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