A 844606

Cat. No. 4477

A 844606 C20H20N2O2 [861119-08-6]

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Chemical Name: 2-(Hexahydro-5-methylpyrrolo[3,4-c]pyrrol-2(1H)-yl)-9H-xanthen-9-one

Biological Activity

Selective α7 nicotinic acetylcholine receptor (nAChR) partial agonist (EC50 values are 1.4 and 2.2 μM at human and rat receptors respectively). Displays no measurable effect on α4β2 nAChRs. Stimulates α7 nAChR-induced ERK1/2 phosphorylation in PC12 cells.

Technical Data

M.Wt:
320.38
Formula:
C20H20N2O2
Solubility:
Soluble to 5 mM in ethanol with gentle warming
Purity:
>99 %
Storage:
Store at -20°C
CAS No:
861119-08-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Briggs et al (2008) Alpha7 nicotinic acetylcholine receptor agonist properties of tilorone and related tricyclic analogues. Br.J.Pharmacol. 153 1054. PMID: 18157163.

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Keywords: A 844606, supplier, A844606, nicotinic, acetylcholine, receptors, alpha7, a7, agonists, nAChR, α7, Tocris Bioscience, Nicotinic (α7) Receptor Agonist products

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