Cat. No. 4477
Chemical Name: 2-(Hexahydro-5-methylpyrrolo[3,4-c]
Biological ActivitySelective α7 nicotinic acetylcholine receptor (nAChR) partial agonist (EC50 values are 1.4 and 2.2 μM at human and rat receptors respectively). Displays no measurable effect on α4β2 nAChRs. Stimulates α7 nAChR-induced ERK1/2 phosphorylation in PC12 cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Briggs et al (2008) Alpha7 nicotinic acetylcholine receptor agonist properties of tilorone and related tricyclic analogues. Br.J.Pharmacol. 153 1054. PMID: 18157163.
If you know of a relevant reference for A 844606 please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses A 844606 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: A 844606, supplier, A844606, nicotinic, acetylcholine, receptors, alpha7, a7, agonists, nAChR, α7, Tocris Bioscience, Nicotinic (α7) Receptor Agonist products
Find multiple products by catalog number
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.