Cardionogen 1

Cat. No. 4475

Cardionogen 1 C13H14N4OS [577696-37-8]

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Chemical Name: 6-Cyclohexyl-3-(2-furanyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole

Biological Activity

Wnt signaling modulator. Potently inhibits Wnt/β-catenin-dependent transcription in murine ES cells (EC50 = 23 nM) and zebrafish embryos. Enlarges heart size via cardiomyocyte hyperplasia; induces ES cell cardiac differentiation.

Technical Data

M.Wt:
274.34
Formula:
C13H14N4OS
Solubility:
Soluble to 20 mM in DMSO and to 10 mM in ethanol
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
577696-37-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Ni et al (2011) Discovering small molecules that promote cardiomyocyte generation by modulating Wnt signaling. Chem.Biol. 18 1658. PMID: 22195568.

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Keywords: Cardionogen 1, supplier, Cardionogen1, Wnt/B-catenin, beta-catenin, β-catenin, embryonic, stem, cells, inhibitors, inhibits, cardiac, hyperplasia, differentiation, Tocris Bioscience, β-catenin products

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