Cardionogen 1

Cat. No. 4475

Cardionogen 1 C13H14N4OS [577696-37-8]

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Chemical Name: 6-Cyclohexyl-3-(2-furanyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole

Biological Activity

Wnt signaling modulator. Potently inhibits Wnt/β-catenin-dependent transcription in murine ES cells (EC50 = 23 nM) and zebrafish embryos. Enlarges heart size via cardiomyocyte hyperplasia; induces ES cell cardiac differentiation.

Technical Data

Soluble to 20 mM in DMSO and to 10 mM in ethanol
>99 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Ni et al (2011) Discovering small molecules that promote cardiomyocyte generation by modulating Wnt signaling. Chem.Biol. 18 1658. PMID: 22195568.

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Keywords: Cardionogen 1, supplier, Cardionogen1, Wnt/B-catenin, beta-catenin, β-catenin, embryonic, stem, cells, inhibitors, inhibits, cardiac, hyperplasia, differentiation, Tocris Bioscience, β-catenin products

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