Cat. No. 4471
Chemical Name: 6-[4-[2-(4-Morpholinyl)ethoxy]pheny
Biological ActivitySelective VEGFR-2 inhibitor (IC50 values are 161, 3558, 8038 and > 30000 nM for VEGFR-2, BMPR-I, AMPK and TGFβR-I respectively). Displays antiangiogenic activity in vitro and in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Hao et al (2010) In vivo structure-activity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitors. ACS Chem.Biol. 5 245. PMID: 20020776.
Fraley et al (2002) Optimization of a pyrazolo[1,5-a]pyrimidine class of KDR kinase inhibitors: improvements in physical properties enhance cellular activity and pharmacokinetics. Bioorg.Med.Chem.Lett. 12 3537. PMID: 12443771.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses DMH4 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: DMH4, supplier, VEGFR-2, inhibitors, inhibits, dorsomorphin, vascular, endothelial, growth, factor, receptor-2, KDR, Tocris Bioscience, VEGFR Inhibitor products
Find multiple products by catalog number
New Products in this Area
Potent and selective pan-Trk inhibitor; peripherally restrictedHIOC
Selective TrkB receptor agonist; neuroprotectantAV 412
Potent inhibitor of EGFR, ErbB2 and Abl receptor tyrosine kinasesCP 724714
Potent and selective ErbB2 inhibitor
Follow Tocris on LinkedIn
Visit our LinkedIn page for the latest Tocris news, events and updates.