EMD 281014 hydrochloride

Cat. No. 4470

EMD 281014 hydrochloride C22H21FN4O.HCl [443144-27-2]

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Chemical Name: 7-[[4-[2-(4-Fluorophenyl)ethyl]-1-piperazinyl]carbonyl]-1H-indole-3-carbonitrile hydrochloride

Biological Activity

Selective 5-HT2A antagonist; displays high affinity for human 5-HT2A over 5-HT2C receptors (Ki values are 0.87 and 557 nM respectively). Exhibits low off-target activity (Ki values are >1000 and 1268 nM for human D2 receptors and IKr channels, respectively).

Technical Data

M.Wt:
412.89
Formula:
C22H21FN4O.HCl
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
443144-27-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Ladduwahetty et al (2006) A new class of selective, non-basic 5-HT2A receptor antagonists. Bioorg.Med.Chem.Lett. 16 3201. PMID: 16632354.

Patel et al (2004) The highly selective 5-hydroxytryptamine (5-HT)2A receptor antagonist, EMD 281014, significantly increases swimming and decreases immobility in male congenital learned helpless rats in the forced swim test. Synapse 52 73. PMID: 14755634.

Bartoszyk et al (2003) EMD 281014, a new selective serotonin 5-HT2A receptor antagonist. Eur.J.Pharmacol. 473 229.

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Keywords: EMD 281014 hydrochloride, supplier, EMD281014, 5-HT2A, selective, serotonergics, antagonists, h5-HT2A, h5-HT2C, Tocris Bioscience, 5-HT2A Receptor Antagonist products

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