VU 0364770

Cat. No. 4469

VU 0364770 C12H9ClN2O [61350-00-3]

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Chemical Name: N-(3-Chlorophenyl)-2-pyridinecarboxamide

Biological Activity

Positive allosteric modulator at mGlu4 receptors (EC50 = 290 nM in mGlu4-expressing HEK 293 cells). Reverses haloperidol-induced catalepsy in rats; prevents attentional deficit and forelimb asymmetry in a rodent model of Parkinson's disease. Exhibits affinity for MAO-B and MAO-A (Ki values are 0.72 μM and 8.5 μM respectively). Brain penetrant.

Technical Data

Soluble to 100 mM in DMSO
>99 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Jones et al (2012) The metabotropic glutamate receptor 4-positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's disease. J.Pharmacol.Exp.Ther. 340 404. PMID: 22088953.

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Keywords: VU 0364770, supplier, VU0364770, glutamate, receptor, Glu, mGlu4, mGluR4, postive, allosteric, modulators, pams, brain, penetrant, Tocris Bioscience, Glutamate (Metabotropic) Group III Receptor Modulator products

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