Cat. No. 4469
Chemical Name: N-(3-Chlorophenyl)-2-pyridinecarbox
Biological ActivityPositive allosteric modulator at mGlu4 receptors (EC50 = 290 nM in mGlu4-expressing HEK 293 cells). Reverses haloperidol-induced catalepsy in rats; prevents attentional deficit and forelimb asymmetry in a rodent model of Parkinson's disease. Exhibits affinity for MAO-B and MAO-A (Ki values are 0.72 μM and 8.5 μM respectively). Brain penetrant.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Jones et al (2012) The metabotropic glutamate receptor 4-positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's disease. J.Pharmacol.Exp.Ther. 340 404. PMID: 22088953.
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Keywords: VU 0364770, supplier, VU0364770, glutamate, receptor, Glu, mGlu4, mGluR4, postive, allosteric, modulators, pams, brain, penetrant, Tocris Bioscience, Glutamate (Metabotropic) Group III Receptor Modulator products