AT 1015

Cat. No. 4468

AT 1015 C29H33N3O2.HCl [190508-50-0]

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Chemical Name: N-[2-[4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-piperidinyl]ethyl]-1-formyl-4-piperidinecarboxamide hydrochloride

Biological Activity

Long-acting 5-HT2A receptor antagonist; inhibits vasoconstriction and blocks platelet aggregation. Prolongs clotting time in a rat model of thrombus formation; ameliorates laurate-induced peripheral vascular lesions in rodents.

Technical Data

M.Wt:
492.05
Formula:
C29H33N3O2.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>97 %
Storage:
Store at +4°C
CAS No:
190508-50-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Kihara et al (2001) Antithrombotic activity of AT-1015, a potent 5-HT(2A) receptor antagonist, in rat arterial thrombosis model and its effect on bleeding time. Eur.J.Pharmacol. 433 157. PMID: 11755147.

Rashid et al (2001) Assessment of affinity and dissociation ability of a newly synthesized 5-HT2 antagonist, AT-1015: comparison with other 5-HT2 antagonists. Jpn.J.Pharmacol. 87 189. PMID: 11885967.

Kihara et al (2000) AT-1015, a novel serotonin (5-HT)2 receptor antagonist, blocks vascular and platelet 5-HT2A receptors and prevents the laurate-induced peripheral vascular lesions in rats. J.Cardiovasc.Pharmacol. 35 523. PMID: 10774780.

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Keywords: AT 1015, supplier, AT1015, supplier, serotonin, 5-HT2, receptor, antagonists, vasoconstriction, antithrombotics, antiplatelet, aggregation, Tocris Bioscience, 5-HT2A Receptor Antagonist products

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