PHP 501 trifluoroacetate
Cat. No. 4466
Chemical Name: 4-(5-[1,1'-Biphenyl]-3-yl-1-hydroxy-
Biological ActivityPotent GABAA antagonist (Ki = 0.0028 μM at rat GABAA receptors; IC50 = 0.024 μM at human α1β2γ2 GABAA-expressing tsA201 cells). Displays no inhibitory activity at hGAT-1, hGAT-2, hGAT-3 or hBGT-1 GABA transporters.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Møller et al (2010) Novel 4-(piperidin-4-yl)-1-hydroxypyrazoles as gamma-aminobutyric acid(A) receptor ligands: synthesis, pharmacology, and structure-activity relationships. J.Med.Chem. 53 3417. PMID: 20355712.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for PHP 501 trifluoroacetate include:
León et al (2016) Direct actions of kisspeptins on GnRH neurons permit attainment of fertility but are insufficient to fully preserve gonadotropic axis activity. Sci.Rep. 6 19206. PMID: 26755241.
León et al (2016) Direct Actions of Kisspeptins on GnRH Neurons Permit Attainment of Fertility but are Insufficient to Fully Preserve Gonadotropic Axis Activity. Mucosal Immunol 6 19206. PMID: 26755241.
Do you know of a great paper that uses PHP 501 trifluoroacetate from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: PHP 501 trifluoroacetate, supplier, GABAA, receptors, antagonists, potent, PHP501, Tocris Bioscience, GABAA Receptor Antagonist products
Find multiple products by catalog number
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.