PHP 501 trifluoroacetate

Cat. No. 4466

PHP 501 trifluoroacetate C20H21N3O.CF3CO2H [1236105-75-1]

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Chemical Name: 4-(5-[1,1'-Biphenyl]-3-yl-1-hydroxy-1H-pyrazol-4-yl)piperidine trifluoroacetate

Biological Activity

Potent GABAA antagonist (Ki = 0.0028 μM at rat GABAA receptors; IC50 = 0.024 μM at human α1β2γ2 GABAA-expressing tsA201 cells). Displays no inhibitory activity at hGAT-1, hGAT-2, hGAT-3 or hBGT-1 GABA transporters.

Technical Data

Soluble to 100 mM in DMSO
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Møller et al (2010) Novel 4-(piperidin-4-yl)-1-hydroxypyrazoles as gamma-aminobutyric acid(A) receptor ligands: synthesis, pharmacology, and structure-activity relationships. J.Med.Chem. 53 3417. PMID: 20355712.

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Citations are publications that use Tocris products. Selected citations for PHP 501 trifluoroacetate include:

León et al (2016) Direct actions of kisspeptins on GnRH neurons permit attainment of fertility but are insufficient to fully preserve gonadotropic axis activity. Sci.Rep. 6 19206. PMID: 26755241.

León et al (2016) Direct Actions of Kisspeptins on GnRH Neurons Permit Attainment of Fertility but are Insufficient to Fully Preserve Gonadotropic Axis Activity. Mucosal Immunol 6 19206. PMID: 26755241.

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Keywords: PHP 501 trifluoroacetate, supplier, GABAA, receptors, antagonists, potent, PHP501, Tocris Bioscience, GABAA Receptor Antagonist products

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