Cat. No. 4464

IOX 1 C10H7NO3 [5852-78-8]

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Alternative Name: 5-carboxy-8HQ

Chemical Name: 8-Hydroxy-5-quinolinecarboxylic acid

Biological Activity

Histone demethylase JMJD inhibitor (IC50 values are 0.12, 0.17, 0.2, 0.3, 0.6 and 1 μM for JMJD3, JMJD1A, JMJD2A, JMJD2E, JMJD2C and UTX respectively). Cell permeable; inhibits JMJD2A-mediated H3K9me3 demethylation in HeLa cells.

Licensing Information

This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the IOX 1 summary on the SGC website.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in 1eq. NaOH
>99 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

King et al (2010) Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors. PLoS One. 5 e15535. PMID: 21124847.

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Keywords: IOX 1, supplier, IOX1, histone, demethylases, inhibitors, inhibits, JMJD2, JMJD3, JMJD6, JMJD1, UTX, H3K9me3, demethylation, demethylates, cell, permeable, in, vitro, activity, sgc, Tocris Bioscience, Histone Demethylase Inhibitor products

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