Cat. No. 4463
Chemical Name: 1,2,3,4-Tetrahydro-2-[[5-(methylthi
Biological ActivityRev-Erbα antagonist; inhibits Rev-Erbα transcriptional repression (EC50 = 0.47 μM). Blocks activity of Rev-Erbα agonist GSK 4112 (Cat. No. 3663) in HEK293 cells. Increases expression of glucose-regulating genes, G6Pase and PEPCK in HepG2 cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Kojetin et al (2011) Identification of SR8278, a synthetic antagonist of the nuclear heme receptor REV-ERB. ACS Chem. Biol. 6 131. PMID: 21043485.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses SR 8278 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: SR 8278, supplier, SR8278, REV-ERB, heme, nuclear, receptors, antagonists, inhibits, glucose, regulation, Tocris Bioscience, Rev-Erb Receptor Antagonist products
Find multiple products by catalog number
New Products in this Area
Synthetic retinoid; induces differentiation of stem cells
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.