Cat. No. 4463
Chemical Name: 1,2,3,4-Tetrahydro-2-[[5-(methylthi
Biological ActivityRev-Erbα antagonist; inhibits Rev-Erbα transcriptional repression (EC50 = 0.47 μM). Blocks activity of Rev-Erbα agonist GSK 4112 (Cat. No. 3663) in HEK293 cells. Increases expression of glucose-regulating genes, G6Pase and PEPCK in HepG2 cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Kojetin et al (2011) Identification of SR8278, a synthetic antagonist of the nuclear heme receptor REV-ERB. ACS Chem. Biol. 6 131. PMID: 21043485.
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Keywords: SR 8278, supplier, SR8278, REV-ERB, heme, nuclear, receptors, antagonists, inhibits, glucose, regulation, Tocris Bioscience, Rev-Erb Receptor Antagonist products
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