Cat. No. 4463
Chemical Name: 1,2,3,4-Tetrahydro-2-[[5-(methylthi
Biological ActivityRev-Erbα antagonist; inhibits Rev-Erbα transcriptional repression (EC50 = 0.47 μM). Blocks activity of Rev-Erbα agonist GSK 4112 (Cat. No. 3663) in HEK293 cells. Increases expression of glucose-regulating genes, G6Pase and PEPCK in HepG2 cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Kojetin et al (2011) Identification of SR8278, a synthetic antagonist of the nuclear heme receptor REV-ERB. ACS Chem. Biol. 6 131. PMID: 21043485.
If you know of a relevant reference for SR 8278 please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses SR 8278 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: SR 8278, supplier, SR8278, REV-ERB, heme, nuclear, receptors, antagonists, inhibits, glucose, regulation, Tocris Bioscience, Rev-Erb Receptor Antagonist products
Find multiple products by catalog number
New Products in this Area
Synthetic progesterone analogC-DIM 12
Nurr1 activator; inhibits NF-κB-dependent gene expression(S)-Equol
Potent estrogen receptor β (ERβ) agonistAilanthone
Potent inhibitor of androgen receptor (AR)(±)-ML 209
RORγt inverse agonist; suppresses Th17 cell differentiationAGN 193109
High affinity pan-RAR antagonistSR 9243
Selective LXR inverse agonist
Follow Tocris on LinkedIn
Visit our LinkedIn page for the latest Tocris news, events and updates.