NS 3623

Cat. No. 4462

NS 3623 C15H10BrF3N6O [343630-41-1]

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Chemical Name: N-[4-Bromo-2-(1H-tetrazol-5-yl-phenyl]-N'-[3-(trifluoromethyl)phenyl]-urea

Biological Activity

KV11.1 (hERG) and KV4.3 channel activator. Activates the IKr and Ito currents and displays antiarrhythmic activity. May also act as a partial blocker of KV11.1 channels. Displays selectivity over the key cardiac potassium channels, KV7.1 (KCNQ1) and KV1.5. Suitable for both in vitro and in vivo use.

Technical Data

Soluble to 100 mM in DMSO
>99 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Calloe et al (2016) A dual potassium channel activator improves repolarization reserve and normalizes ventricular action potentials. Biochem.Pharmacol. 108 36. PMID: 27002181 .

George (2009) Restoring repolarization in LQT3. Heart Rhythm. 6 107. PMID: 19121809 .

Hansen et al (2007) Pharmacological activation of rapid delayed rectifier potassium current suppresses bradycardia-induced triggered activity in the isolated guinea pig heart. J.Pharmacol.Exp.Ther. 321 996. PMID: 17325228.

Hansen et al (2006) Biophysical characterization of the new human ether-a-go-go-related gene channel opener NS3623 [N-(4-bromo-2-(1H-tetrazol-5-yl)-phenyl)-N'-(3'-trifluoromethylphenyl)urea]. Mol.Pharmacol. 70 1319. PMID: 16825484.

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Keywords: NS 3623, supplier, hERG, activators, cardiac, ether-a-go-go, IKr, Kv11.1, potassium, channels, voltage-gated, Kv, anti-arrhythmic, NS3623, Kv4.3, Ito, Tocris Bioscience, Voltage-gated Potassium (KV) Channel Activator products

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