Cat. No. 4460
Chemical Name: α,α,α-Trifluorothymidine
Biological ActivityNucleoside analog; inhibitor of thymidylate synthase. Incorporation of the triphosphate form into DNA induces DNA fragmentation. Exhibits antitumor activity.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Yu et al (2015) Small molecules enhance CRISPR genome editing in pluripotent stem cells. Cell Stem Cell 16 142. PMID: 25658371.
Okayama et al (2012) Involvement of concentrative nucleoside transporter 1 in intestinal absorption of trifluorothymidine, a novel antitumor nucleoside, in rats. J.Pharmacol.Exp.Ther. 340 457. PMID: 22076553.
Emura et al (2005) Potentiation of the antitumor activity of α, α, α-trifluorothymidine by the co-administration of an inhibitor of thymidine phosphorylase at a suitable molar ratio in vivo. Int.J.Oncol. 27 449. PMID: 16010427.
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Keywords: Trifluorothymidine, supplier, antitumor, anticancer, nucleoside, analog, thymidylate, synthase, inhibitors, inhibits, Tocris Bioscience, Other Synthase/Synthetase Inhibitor products