Cat. No. 4460

Trifluorothymidine C10H11F3N2O5 [70-00-8]

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Chemical Name: α,α,α-Trifluorothymidine

Biological Activity

Nucleoside analog; inhibitor of thymidylate synthase. Incorporation of the triphosphate form into DNA induces DNA fragmentation. Exhibits antitumor activity.

Technical Data

Soluble to 50 mM in water and to 100 mM in DMSO
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Yu et al (2015) Small molecules enhance CRISPR genome editing in pluripotent stem cells. Cell Stem Cell 16 142. PMID: 25658371.

Okayama et al (2012) Involvement of concentrative nucleoside transporter 1 in intestinal absorption of trifluorothymidine, a novel antitumor nucleoside, in rats. J.Pharmacol.Exp.Ther. 340 457. PMID: 22076553.

Emura et al (2005) Potentiation of the antitumor activity of α, α, α-trifluorothymidine by the co-administration of an inhibitor of thymidine phosphorylase at a suitable molar ratio in vivo. Int.J.Oncol. 27 449. PMID: 16010427.

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Keywords: Trifluorothymidine, supplier, antitumor, anticancer, nucleoside, analog, thymidylate, synthase, inhibitors, inhibits, Tocris Bioscience, Other Synthase/Synthetase Inhibitor products

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