TC-S 7005

Cat. No. 4459

TC-S 7005 C21H17N3O3 [1082739-92-1]

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Chemical Name: 3-(1,3-Benzodioxol-5-yl)-N-[(1S)-1-phenylethyl]-isoxazolo[5,4-c]pyridin-5-amine

Biological Activity

Potent and selective polo-like kinase 2 (PLK2) inhibitor (IC50 = 4 nM). Shows selectivity for PLK2 over PLK3 and PLK1 (IC50 values are 24 and 214 nM respectively). Induces mitotic arrest and cell death in HCT 116 colorectal cells.

Technical Data

M.Wt:
359.38
Formula:
C21H17N3O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
1082739-92-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Hanan et al (2008) Design and synthesis of 2-amino-isoxazolopyridines as Polo-like kinase inhibitors. Bioorg.Med.Chem.Lett. 18 5186. PMID: 18790636.

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Keywords: TC-S 7005, supplier, TC-S7005, potent, selective, PLK2, inhibitors, inhibits, PLK1, PLK3, TCS7005, mitosis, PLK, cell, cycle, kinases, polo-like, polo, like, Tocris Bioscience, Polo-like Kinase Inhibitor products

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