Cat. No. 4456
Chemical Name: 3-(10,11-Dihydro-5H-dibenzo[a,d]cyc
Biological ActivityInhibitor of serotonin and noradrenaline uptake; also activates α2A-adrenoceptors and antagonizes 5-HT2 receptors. Displays antinociceptive activity. Tricyclic antidepressant (TCA). Also a TrkA/B agonist. Induces neurite outgrowth in PC12 cells.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Sawynok et al (2001) Antidepressants as analgesics: an overview of central and peripheral mechanisms of action. J.Psychiatry Neurosci. 26 21. PMID: 11212590.
Ghelardini et al (2000) Antinociception induced by amitriptyline and imipramine is mediated by α2A-adrenoceptors. Jpn.J.Pharmacol. 82 130. PMID: 10877531.
Sanchez and Hyttel (1999) Comparison of the effects of antidepressants and their metabolites on reuptake of biogenic amines and on receptor binding. Cell.Mol.Neurobiol. 19 467. PMID: 10379421.
Merck Index 12 85.
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Keywords: Amitriptyline hydrochloride, supplier, serotonin, serotonergics, 5-HT, noradrenalin, noradrenaline, net, sert, reuptake, inhibitors, inhibits, tca, tricyclic, antidepressants, neurotrophic, factors, TRKA, B, tropomyosin, related, kinases, agonists, agonism, Tocris Bioscience, 5-HT Transporter Inhibitor products
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