Cat. No. 4456
Chemical Name: 3-(10,11-Dihydro-5H-dibenzo[a,d]cyc
Biological ActivityInhibitor of serotonin and noradrenaline uptake; also activates α2A-adrenoceptors and antagonizes 5-HT2 receptors. Displays antinociceptive activity. Tricyclic antidepressant (TCA). Also a TrkA/B agonist. Induces neurite outgrowth in PC12 cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Sawynok et al (2001) Antidepressants as analgesics: an overview of central and peripheral mechanisms of action. J.Psychiatry Neurosci. 26 21. PMID: 11212590.
Ghelardini et al (2000) Antinociception induced by amitriptyline and imipramine is mediated by α2A-adrenoceptors. Jpn.J.Pharmacol. 82 130. PMID: 10877531.
Sanchez and Hyttel (1999) Comparison of the effects of antidepressants and their metabolites on reuptake of biogenic amines and on receptor binding. Cell.Mol.Neurobiol. 19 467. PMID: 10379421.
Merck Index 12 85.
If you know of a relevant reference for Amitriptyline hydrochloride please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses Amitriptyline hydrochloride from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Amitriptyline hydrochloride, supplier, serotonin, serotonergics, 5-HT, noradrenalin, noradrenaline, net, sert, reuptake, inhibitors, inhibits, tca, tricyclic, antidepressants, neurotrophic, factors, TRKA, B, tropomyosin, related, kinases, agonists, agonism, Tocris Bioscience, 5-HT Transporter Inhibitor products
Find multiple products by catalog number
New Products in this Area
Dopamine uptake inhibitor
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.