Amitriptyline hydrochloride

Cat. No. 4456

Amitriptyline hydrochloride C20H23N.HCl [549-18-8]

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Chemical Name: 3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine hydrochloride

Biological Activity

Inhibitor of serotonin and noradrenaline uptake; also activates α2A-adrenoceptors and antagonizes 5-HT2 receptors. Displays antinociceptive activity. Tricyclic antidepressant (TCA). Also a TrkA/B agonist. Induces neurite outgrowth in PC12 cells.

Technical Data

M.Wt:
313.86
Formula:
C20H23N.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
549-18-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Sawynok et al (2001) Antidepressants as analgesics: an overview of central and peripheral mechanisms of action. J.Psychiatry Neurosci. 26 21. PMID: 11212590.

Ghelardini et al (2000) Antinociception induced by amitriptyline and imipramine is mediated by α2A-adrenoceptors. Jpn.J.Pharmacol. 82 130. PMID: 10877531.

Sanchez and Hyttel (1999) Comparison of the effects of antidepressants and their metabolites on reuptake of biogenic amines and on receptor binding. Cell.Mol.Neurobiol. 19 467. PMID: 10379421.

Merck Index 12 85.

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Keywords: Amitriptyline hydrochloride, supplier, serotonin, serotonergics, 5-HT, noradrenalin, noradrenaline, net, sert, reuptake, inhibitors, inhibits, tca, tricyclic, antidepressants, neurotrophic, factors, TRKA, B, tropomyosin, related, kinases, agonists, agonism, Tocris Bioscience, 5-HT Transporter Inhibitor products

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