Diclofenac sodium salt
Cat. No. 4454
Chemical Name: 2-[(2,6-Dichlorophenyl)amino]benzen
Biological ActivityNonsteroidal, anti-inflammatory drug (NSAID); inhibits COX-1 and COX-2 (IC50 values are 0.075 μM for COX-1 and 0.038 μM for COX-2 in human whole blood assay).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Warner et al (1999) Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis. Proc.Natl.Acad.Sci.USA 96 7563. PMID: 10377455.
Bort et al (1998) Diclofenac toxicity to hepatocytes: a role for drug metabolism in cell toxicity. J.Pharmacol.Exp.Ther. 288 65. PMID: 9862754.
Laneuville et al (1994) Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugs. J.Pharmacol.Exp.Ther. 271 927. PMID: 7965814.
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Keywords: Diclofenac sodium salt, supplier, nsaids, non-steroidal, anti-inflammatories, anti-inflammatory, cox-1, cox-2, cyclooxygenase, inhibitors, inhibits, Tocris Bioscience, Cyclooxygenase Inhibitor products
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